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related to: What is triple therapy for COPD?Learn How This COPD Inhaler Option May Help To Reduce Your COPD Flare-Ups. Discover How This Triple Therapy Option May Help To Improve Your COPD Symptoms.
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What is triple therapy for COPD?
Should I start triple therapy if I have COPD?
Is triple therapy better than dual therapy for COPD?
Jan 30, 2023 · The recommended pharmacological treatment for a patient first diagnosed with COPD is a long-acting bronchodilator, either long-acting muscarinic antagonists (LAMA), long-acting β 2 -agonists (LABA) or their combination [1].
- Samy Suissa
- ERJ Open Res. 2023 Jan; 9(1): 00615-2022.
- 10.1183/23120541.00615-2022
- 2023/01
- Overview
- What is triple therapy?
- What is dual therapy?
- Does triple therapy work better than dual therapy?
- Who is a candidate?
- What are the side effects?
- The takeaway
Triple therapy for COPD combines three inhaled medications to help you breathe easier. This can include medications to reduce swelling, widen the airway, and relax the muscles in your airway.
To treat COPD, you may need to take a combination of several different medications. Some of these drugs relax your airways. Others bring down swelling in your lungs. The goal of taking more than one drug together is to help you breathe easier.
One way to deliver COPD drugs is through an inhaler. When you breathe into this L-shaped device, it delivers the medication straight into your lungs.
You can take each drug you need through separate inhalers. Or, you can take two or three drugs in a single inhaled dose.
Triple therapy combines three inhaled COPD drugs:
•a corticosteroid to bring down swelling in your airways
•a long-acting beta-agonist to relax the muscles around your airway
•an anticholinergic drug to widen the large airways
In the past, you’d take triple therapy in two separate inhalers. One inhaler contained an inhaled corticosteroid and a long-acting beta-agonist. The other contained an anticholinergic.
In 2017, the FDA approved Trelegy Ellipta, the first triple therapy in one inhaler. It combines:
Dual therapy for COPD combines two drugs into one inhaler. This treatment has been around since 2013.
Some dual therapies combine an anticholinergic drug with a long-acting beta-agonist:
•Anoro Ellipta (umeclidinium and vilanterol)
•Duaklir (aclidinium bromide and formoterol fumarate)
Another combines a long-acting beta-agonist with a corticosteroid:
•Breo Ellipta (fluticasone furoate and vilanterol)
Triple therapy seems to reduce the number of flares and improve quality of life in people with COPD better than dual therapy. But it may increase your risk of side effects.
Studies show that people who are on triple therapy have fewer COPD flares than those who are on dual therapy. They’re also less likely to be hospitalized for attacks of COPD symptoms.
An analysis of 21 studies found that using triple therapy reduced the number of moderate-to-severe COPD flares, improved lung function, and led to a better quality of life compared to dual therapy. One downside was that people on triple therapy were more likely to get pneumonia.
Triple therapy in a single inhaler doesn’t work better than the same treatment given in three separate inhalers, research suggests. Convenience is the main advantage of taking the three drugs together. Easier dosing may help people stick with their treatment regimen and not miss doses.
Trelegy Ellipta is approved for people with COPD, including those with chronic bronchitis and emphysema. Your doctor may prescribe this drug if you’ve been taking dual therapy, but your symptoms haven’t improved enough. Trelegy Ellipta is not meant for people with asthma.
Dual therapies like Anoro Ellipta and Duaklir are approved for the maintenance treatment of COPD. Breo Ellipta is also approved to treat asthma in adults.
The most common side effects of triple therapy include:
•headache
•back pain
•a change in your sense of taste
•diarrhea
•cough
Your doctor might suggest that you go on triple therapy if the dual therapy inhaler you’ve been on hasn’t controlled your COPD symptoms well enough. Switching to triple therapy may work better at helping you avoid symptom flares.
Before you switch to a new treatment, ask your doctor what side effects it could cause. Find out if you’re at increased risk of these problems because of your health history or other medications you take. Ask how to manage any side effects you experience.
Aug 10, 2021 · Triple therapy for COPD combines three drugs to help control symptoms. Learn more about the medication, including what it comprises, its safety, and its effectiveness.
Jan 14, 2022 · A recent network meta-analysis aimed to directly compare triple ICS/LABA/LAMA with corresponding either dual LABA/LAMA or ICS/LABA therapies administered as FDC via the same inhaler device has provided important information on the possible positioning of triple therapy FDC in the treatment of COPD. 29 It included ETHOS (Efficacy and Safety of ...
A current hot topic in COPD is that two “fixed triple” combinations of an inhaled corticosteroid (ICS), a long-acting β2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) in a single inhaler have become available for patients with COPD, and a third triple therapy is in advanced development with the first large randomised ...
- Lowie E.G.W. Vanfleteren, Anders Ullman, Anita Nordenson, Anders Andersson, Kristina Andelid, Leonar...
- 2019
Jun 24, 2020 · Triple fixed-dose regimens of an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long-acting β 2 -agonist (LABA) for chronic obstructive pulmonary disease (COPD)...
Nov 6, 2018 · Use of triple therapy resulted in a lower rate of moderate or severe exacerbations of COPD, better lung function, and better health related quality of life than dual therapy or monotherapy in patients with advanced COPD.
