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  2. pubmed.ncbi.nlm.nih.gov › 27452453Triple inhaled therapy for chronic obstructive pulmonary disease

    Triple inhaled therapy might be particularly useful in patients with severe to very severe COPD, above all in those with peripheral blood or sputum eosinophilia, asthma-COPD overlap syndrome (ACOS) or frequent exacerbators.

  3. www.nejm.org › doi › fullTriple Inhaled Therapy at Two Glucocorticoid Doses in ...

    Jun 24, 2020 · Triple therapy with an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long-acting β 2 -agonist (LABA) was shown to lead to a lower risk of COPD exacerbations, a greater...

    • Klaus F. Rabe, Fernando J. Martinez, Gary T. Ferguson, Chen Wang, Dave Singh, Jadwiga A. Wedzicha, R...
    • 2020

  4. www.bmj.com › content › 363Triple therapy in the management of chronic obstructive ...

    Nov 6, 2018 · The Global Initiative for Obstructive Lung Disease (GOLD) management strategy recommend triple therapy with inhaled corticosteroids, LABA, and LAMA for GOLD group D patients who develop further exacerbations after receiving initial dual treatment of LABA and LAMA. 3 4 Triple therapy using multiple inhalers has been shown to improve forced expira...

    • Yayuan Zheng, Jianhong Zhu, Yuyu Liu, Weiguang Lai, Chunyu Lin, Kaifen Qiu, Junyan Wu, Weimin Yao
    • 2018

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  6. www.ncbi.nlm.nih.gov › pmc › articlesTriple therapy in COPD: understanding the data - PMC

    Jan 30, 2023 · Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial. Lancet 2018; 391: 1076–1084. doi: 10.1016/S0140-6736(18)30206-X [Google Scholar]

    • Samy Suissa
    • ERJ Open Res. 2023 Jan; 9(1): 00615-2022.
    • 10.1183/23120541.00615-2022
    • 2023/01

  7. www.nejm.org › doi › fullOnce-Daily Single-Inhaler Triple versus Dual Therapy in ...

    Apr 18, 2018 · Triple inhaled therapy for chronic obstructive pulmonary disease (COPD) comprises an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long-acting β 2 -agonist (LABA).

    • David A. Lipson, Frank Barnhart, Noushin Brealey, Jean Brooks, Gerard J. Criner, Nicola C. Day, Mark...
    • 2018

  8. www.ncbi.nlm.nih.gov › pmc › articlesBeyond Dual Bronchodilation – Triple Therapy, When and Why

    Jan 14, 2022 · The evidence generated by pivotal RCTs supports the use of triple therapy in patients who present for the first time and have severe airway obstruction, are symptomatic, have had frequent moderate or severe exacerbations in the previous year, and have peripheral eosinophilia.

  9. www.nature.com › articles › s41598/022/18353-yDifferent inhaled corticosteroid doses in triple therapy for ...

    Sep 20, 2022 · Triple therapy with high dose (HD)-ICS exhibited a lower risk of total exacerbation in pre-specified subgroups treated for ≥ 48 weeks than that with low dose (LD)-ICS (odds ratio [OR] =...