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Sep 7, 2017 · The pathogenesis of IAV is related to the morbidity and mortality caused by its infection. These two parameters can be evaluated in mice easily: IAV morbidity is associated with body weight loss in infected mice and the percentage of survival will indicate the mortality rate (Figure 1).
- Laura Rodriguez, Aitor Nogales, Luis Martínez-Sobrido
- 10.3791/55898
- 2017
- J Vis Exp. 2017; (127): 55898.
Sep 25, 2018 · Infection with Influenza A virus (IAV) causes significant cell death within the upper and lower respiratory tract and lung parenchyma. In severe infections, high levels of cell death can...
- Georgia K. Atkin-Smith, Mubing Duan, Weisan Chen, Ivan K. H. Poon
- 2018
Jan 1, 2019 · Each year approximately 3–5 million people suffer from severe influenza infection and of those, approximately 250,000 – 500,000 succumb to the disease. The pathogenesis following IAV infection occurs in two phases. The first phase lasts between 1–3 days and determines the peak virus titer as well as the amount of inflammation associated with that.
- Anshu P Gounder, Adrianus C M Boon
- 10.4049/jimmunol.1801010
- 2019
- 2019/01/01
Secondary bacterial infections are a very common cause of IAV associated morbidity and mortality. The robust inflammatory response that follows infection is important for the control of virus proliferation but is also associated with lung damage, morbidity and death.
- Luciana P. Tavares, Mauro M. Teixeira, Cristiana C. Garcia
- 2017
Oct 12, 2015 · Additionally, secondary bacterial infections, caused mainly by Streptococcus pneumoniae, are one of the main complications and responsible for the enhanced morbidity and mortality associated with IAV infections.
- Alessandro Boianelli, Van Kinh Nguyen, Thomas Ebensen, Kai Schulze, Esther Wilk, Niharika Sharma, Sa...
- 2015
Mar 4, 2018 · There are approximately 5 million clinical infection cases caused by influenza viruses every year and 250,000–500,000 deaths resulted from the annual epidemics around the globe, particularly in people over 65 years old who account for 90% of all influenza-associated deaths in the USA (10).
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Why is secondary bacterial infection a common cause of IAV morbidity & mortality?
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May 2, 2024 · Disease severity and mortality rapidly increase when a new influenza virus emerges, as exemplified by the 1918–1919 H1N1 catastrophe (with more than 40 million deaths) 10, 11 and the emergence...
