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      • Many studies have historically demonstrated that uncertainty as a common feature in threat context may elicit fear and anxiety. The idea of “intolerance of uncertainty” emerges from anxiety-related studies; the key component of which was originally identified as fear of the unknown.
      www.ncbi.nlm.nih.gov/pmc/articles/PMC7704173/
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  2. Nov 22, 2020 · Uncertainty about future events may lead to worry, anxiety, even inability to function. The highly related concept—intolerance of uncertainty (IU)—emerged in the early 1990s, which is further developed into a transdiagnostic risk factor in multiple forms of anxiety disorders.

    • Yuanyuan Gu, Simeng Gu, Yi Lei, Hong Li
    • 10.1155/2020/8866386
    • 2020
    • Neural Plast. 2020; 2020: 8866386.
    • The Danger of Wide-Open Spaces
    • How The Brain Decides
    • When Anxiety Malfunctions
    • Shared, Not Cured

    What we think of as uncertainty is, at its simplest, the brain trying to choose a course of action. From an evolutionary standpoint, this means making decisions that affect survival and reproduction. Uncertainty is a close relative of anxiety. “Uncertainty is not knowing what is going to happen,” said Mazen Kheirbek, Ph.D., an associate professor i...

    Sohal’s work focuses on determining what goes on in the brain when we “weigh these things,” and how that can go wrong in certain disorders. He directs a lab which studies the brain circuits involved with psychiatric conditions like schizophrenia, autism and anxiety. Specifically, he’s looking at how the brain can “filter” information by “learning t...

    Aoife O’Donovan said that in most cases the human brain is quite good at managing anxiety. “We can think in the abstract about multiple scenarios and outcomes and prepare ourselves for them before they even happen,” she says. “The problem is that imagining and predicting and preparing for bad outcomes can take a toll on us psychologically and biolo...

    There’s no telling the future and, so far, no way to turn off our “anxiety neurons,” so how can we better cope with uncertainty? O’Donovan suggests limiting exposure to the news and instead prioritizing behaviors that allow our anxious bodies to return to baseline. That means meditating, exercising, sleeping well, and nurturing social connections. ...

  3. Oct 26, 2021 · Uncertainty can intensify how threatening a situation feels – Ema Tanovic. Tanovic says that many everyday situations elicit the same kind of reaction.

  4. Nov 1, 2020 · Uncertainty is a close relative of anxiety. “Uncertainty is not knowing what is going to happen,” said Mazen Kheirbek, PhD, an associate professor in UC San Francisco’s Department of Psychiatry and Behavioral Sciences. Combine “uncertainty” with “threat” and you get anxiety.

  5. Feb 1, 2020 · Studies show that you're calmer anticipating pain than anticipating uncertainty because pain is certain. Job uncertainty, for example, takes a greater toll on your health than...

  6. Feb 17, 2024 · The term “uncertainty” is most often considered the result of having limited or partial knowledge about a situation or life event, thus making it difficult to control, plan for, or predict the...

  7. Dec 20, 2023 · But many uncertain situations are not so threatening, and in some cases – such as when you travel to an unfamiliar place or meet a new person – the potential outcomes are actually quite positive, even if there are also some undesirable ones (eg, getting lost, being rejected).