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Feb 3, 2022 · However, pharmacological treatment of the severe symptoms, as described below, is invariably required. This variety of neuropathy was originally called “insulin neuritis,” but a more recent review by Gibbons and Freeman suggested the term “treatment-induced neuropathy of diabetes,” as insulin is not the only cause.
Guidelines have recommended antidepressant, anticonvulsant, analgesic, and topical medications—both approved and off-label—to reduce pain in this population. Go to: DISEASE OVERVIEW. Pathogenesis.
- Kenneth Cohen, Nataliya Shinkazh, Jerry Frank, Igor Israel, Chris Fellner
- 2015
May 19, 2021 · Recommended pharmacotherapies include anticonvulsive agents, antidepressant drugs, and topical capsaicin; and tapentadol, which combines opioid agonism and norepinephrine reuptake inhibition, has also recently been approved for use.
- Mayank Gupta, Nebojsa Nick Knezevic, Alaa Abd-Elsayed, Mahoua Ray, Kiran Patel, Bhavika Chowdhury
- 2021
Feb 17, 2020 · Key findings. Diabetic peripheral neuropathy is often inadequately treated, and the role of improving glycaemic control specifically in type-2 diabetes remains unclear. It is crucial to explore the mechanisms of action and effectiveness of available therapies.
- Maher R Khdour
- 2020
May 16, 2023 · 3 Pharmacological treatment of painful diabetic neuropathy. The mainstay of treatment for PDN is pharmacotherapy [11]. Current treatments for PDN are purely symptomatic and do not alter the disease process, and provide a number needed to treat (NNT) for 50% pain relief from 4 to 10 [12].
Feb 3, 2022 · Currently, there is no consensus around treating painful diabetic peripheral neuropathy in a step-wise manner. Among the non-pharmacological interventions, neuromodulation has become a promising alternative.
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First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, amitriptyline, and pregabalin; however, these medications do not restore sensation to...
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