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  2. Feb 10, 2023 · Pain happens, but when it sticks around for a long period of time or feels unbearable, nonaddictive pain medication may sound like a safer alternative to opioids. Most people...

  3. Oct 26, 2022 · Research on non-habit-forming alternatives to opioids for pain relief is ongoing. In a recent study, researchers used computational methods to identify novel compounds that could activate the...

    • Deep Shukla
  4. Apr 21, 2024 · Nonopioid alternatives include nonsteroidal anti-inflammatory drugs, antidepressants, physical therapy, and interventional procedures. Tailored, multimodal approaches are essential to avoiding the risks associated with opioids (eg, addiction and overdose) and are guided by the biopsychosocial model and patient-centered care.

    • Saugat Dey, Bruce M. Vrooman
    • 2024/04/21
    • 2021
    • Acetaminophen. Acetaminophen, the active ingredient in Tylenol, is an over-the-counter (OTC) medication that’s good for relieving headaches, back pain, and arthritis pain.
    • NSAID pills. NSAIDs (nonsteroidal anti-inflammatory drugs) are great for treating mild to moderate pain, such as pain from muscle injury, inflammation (swelling), arthritis, and back issues.
    • Celebrex. A newer NSAID, celecoxib (Celebrex), is available by prescription only. Celebrex is a COX-2 inhibitor medication. It works well as a painkiller and an anti-inflammatory medication.
    • NSAID gels, liquids, patches, and creams. NSAIDs are also available as topical products, like anti-inflammatory creams. These can help with some types of pain, particularly when the pain is centered around a joint or in a specific area of the body.
    • Ibuprofen. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that’s recommended for pain due to inflammation. It’s commonly used for conditions such as osteoarthritis and rheumatoid arthritis.
    • Aspirin. Also known as salicylic acid, aspirin is one of the oldest pain-relieving, nonnarcotic drugs. In addition to having anti-inflammatory properties, it prevents blood clotting.
    • Corticosteroids. Corticosteroids represent a class of synthetic hormones that mimic the effect of your body’s hormones. They work by suppressing your immune response and reducing inflammation.
    • Acetaminophen. Acetaminophen is similar to ibuprofen in its effects of managing pain as an OTC drug. Unlike ibuprofen, it isn’t classified as an NSAID. Acetaminophen has broad pain-relieving applications, meaning it’s recommended for all types of pain.
  5. Nov 21, 2022 · A variety of alternative treatments are available for chronic pain, such as non-opioid medications, physical therapy, acupuncture, yoga, massage, exercise, and biofeedback. Psychotherapy also helps treat the mental challenges and stress that often occur with chronic pain.

  6. Sep 20, 2023 · "Identifying non-opioid drugs that relieve pain will help limit availability of these drugs, as they offer alternatives to replace or reduce opioid use in the clinic.