Search results
The kinin–kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research. [1] It consists of blood proteins that play a role in inflammation, [2] blood pressure control, coagulation and pain.
The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high molecular weight kininogen (HK).
- J W Bryant, Z Shariat-Madar
- 10.2174/187152509789105444
- 2009
- 2009/07
Aug 30, 2023 · We explored the role of Factor XII in activating the plasma kallikrein–kinin system (KKS), the mechanism of activity and control in the KKS, and the function of HK on contact activation proteins on cell membranes.
- 10.3389/fphys.2023.1188816
- 2023
- Front Physiol. 2023; 14: 1188816.
The kinin-kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides.
- Elena Kashuba, James Bailey, David Allsup, Lynn Cawkwell
- 2013
However, humans, rats and mice with a deficiency in one or more components of the kallikrein-kinin-system (KKS) or chronic KKS blockade do not have hypertension. In the kidney, kinins are essential for proper regulation of papillary blood flow and water and sodium excretion.
- Nour Eddine Rhaleb, Xiao Ping Yang, Oscar A. Carretero
- 10.1002/cphy.c100053
- 2011
- 2011/04
Jan 1, 2005 · The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins.
Mar 3, 2021 · The kallikrein kinin system (KKS) consists of serine proteases involved in the production of peptides called kinins, principally bradykinin and Lys-bradykinin (kallidin). The KKS contributes to a variety of physiological processes including inflammation, blood pressure control and coagulation.
