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    • Highly effective

      • Based on registry and real-world studies, fixed triple combination therapy has proven to be highly effective in high-risk patients, improving respiratory function, reducing exacerbation risk, alleviating symptoms, and potentially reducing mortality risk. 4
      www.tandfonline.com/doi/full/10.2147/COPD.S474354

      The Real-World Efficacy of Fixed Triple Inhalation Therapy in ...

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  3. pubmed.ncbi.nlm.nih.gov › 39219564The Real-World Efficacy of Fixed Triple Inhalation Therapy in ...

    Aug 28, 2024 · Purpose: COPD affects more than 300 million people worldwide, requiring inhalation treatment. Novel triple formulations of ICS, LABAs and LAMAs are becoming the mainstay of treatment, however there is still a lack of clinical evidence for personalized therapy.

  4. www.ncbi.nlm.nih.gov › pmc › articlesTriple therapy in COPD: understanding the data - PMC

    Jan 30, 2023 · The Efficacy and Safety of Triple Therapy in Obstructive Lung Disease (ETHOS) trial compared single-inhaler triple therapy (glycopyrrolate, formoterol and budesonide) with its two dual inhalers, LABA-ICS (formoterol and budesonide) and LAMA-LABA (glycopyrrolate and formoterol) over 1 year . This trial enrolled 8509 COPD patients with moderate ...

    • Samy Suissa
    • ERJ Open Res. 2023 Jan; 9(1): 00615-2022.
    • 10.1183/23120541.00615-2022
    • 2023/01

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  6. www.tandfonline.com › doi › fullThe Real-World Efficacy of Fixed Triple Inhalation Therapy in ...

    Preventing exacerbations is the most important task in COPD management, as these events significantly increase patients’ symptoms, worsen their lung function, reduce their quality of life, and increase their mortality risk.

  7. www.ncbi.nlm.nih.gov › pmc › articlesClinical Concepts for Triple Therapy Use in Patients with ...

    Aug 28, 2023 · Role of triple therapy in chronic obstructive pulmonary disease (COPD) management is supported by growing evidence, but consensus is lacking on various aspects.

    • 10.2147/COPD.S424128
    • 2023

  8. www.ncbi.nlm.nih.gov › pmc › articlesBeyond Dual Bronchodilation – Triple Therapy, When and Why

    Jan 14, 2022 · It is therefore necessary to clarify when the use of triple therapy is indicated in COPD patients and when it is preferable to maintain treatment with dual bronchodilation. In this article, we discuss our views based on our experience and what is reported in the literature and try to give answers to these two questions.

  9. journals.sagepub.com › doi › 10Comparative effectiveness and safety of triple therapy and ...

    Jun 14, 2024 · Triple therapy significantly improves lung function, reduces exacerbations, enhances quality of life, and decreases all-cause mortality, but it also carries an increased risk of pneumonia. Additionally, the current evidence is mostly based on moderately to severely elderly patients with a history of smoking.

  10. www.nejm.org › doi › fullMaking Sense of Triple Inhaled Therapy for COPD

    Apr 18, 2018 · Guidelines for the treatment of chronic obstructive pulmonary disease (COPD) have consistently recommended long-acting inhaled bronchodilators — either long-acting muscarinic antagonists (LAMAs)...