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    • Few are from randomized clinical trials

      • "Most of the current recommendations for patients with aortic disease are based on expert opinion and data from observational studies, large registries, and prospective studies, but few are from randomized clinical trials (RCTs)," according to the Writing Group, chaired by Eric M. Isselbacher, MD, MSc, FACC, and Vice Chairs Ourania Preventza, MD, MBA, and James Hamilton Black III, MD, DFSVS.
      www.acc.org/Latest-in-Cardiology/Articles/2022/11/01/01/42/New-in-Clinical-Documents-Diagnosis-Management-of-Aortic-Disease-Focus-of-New-ACC-AHA-Guideline
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  2. Nov 2, 2022 · Recommendations from previously published AHA/ACC guidelines on thoracic aortic disease, peripheral artery disease, and bicuspid aortic valve disease have been updated with new evidence to guide clinicians. In addition, new recommendations addressing comprehensive care for patients with aortic disease have been developed.

  3. Nov 16, 2019 · The Randomized Comparison of Early Surgery versus Conventional Treatment in Very Severe Aortic Stenosis (RECOVERY) trial was designed to compare long-term clinical outcomes of early...

    • Duk-Hyun Kang, Sung-Ji Park, Seung-Ah Lee, Sahmin Lee, Dae-Hee Kim, Hyung-Kwan Kim, Sung-Cheol Yun, ...
    • 2020
  4. There are few randomized clinical trials that inform recommendations in this guideline. The most notable changes from previous guidelines (consideration of a lower surgical threshold for TAA repair in select scenarios and increasing family screening) are significant practice changes backed by suggestive but lower-quality evidence.

  5. The JACC Central Illustration for the ACC/AHA Aortic Disease Guideline identifies the updated surgical intervention thresholds for sporadic aortic root and ascending aortic aneurysms. This clinician tool focuses on Top 10 Take-Home Message #4 and represents a major change in clinical practice.

  6. Nov 13, 2021 · In this randomized clinical trial that included 157 patients, when compared with subjects randomized to the conservative surgery, subjects randomized to early surgical aortic valve replacement had a lower incidence of primary composite end point including all-cause death, acute myocardial infarction, stroke, or unplanned hospitalization for ...

    • Marko Banovic, Svetozar Putnik, Martin Penicka, Gheorghe Doros, Marek A. Deja, Radka Kockova, Martin...
    • 2021
  7. 14 hours ago · The Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis (AVATAR) trial is an investigator-initiated, prospective, multinational, randomized, controlled, parallel-group, event-driven trial that compared the safety and efficacy of early surgery in the treatment of truly asymptomatic patients with severe AS and LV ejection fraction (LVEF) ≥ 50% vs. conservative treatment with watchful waiting strategy and AVR only after symptom onset, or other ...

  8. Nov 1, 2022 · "Most of the current recommendations for patients with aortic disease are based on expert opinion and data from observational studies, large registries, and prospective studies, but few are from randomized clinical trials (RCTs)," according to the Writing Group, chaired by Eric M. Isselbacher, MD, MSc, FACC, and Vice Chairs Ourania Preventza ...