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Understanding why some people may be more at risk of developing prostate cancer is a big step forward in learning how best to tackle and treat the disease. Who is at risk of developing prostate cancer?
Jun 25, 2024 · For decades, doctors treating men with prostate cancer could offer only extreme choices: surgically remove the prostate, target it with radiation that often damaged healthy tissue nearby, or remove the testicles. Treatments commonly caused pain and debilitating side effects such as incontinence and sexual dysfunction.
Feb 29, 2024 · 29 February 2024. Artificial Intelligence has helped scientists reveal a new form of aggressive prostate cancer which could revolutionise how the disease is diagnosed and treated in the future.
- Targeted Screening Based on Individuals' Genetic Profiles
- Improving Diagnosis Through Liquid Biopsies
- Delivering A Radioactive Payload Directly to Cancer Cells
- Targeted Drugs That Are Kinder to Patients
- Better Clinical Trials with Adaptive, Smarter Designs
- Training The Immune System to Fight Cancer
- Manipulating 'Gut Bugs'
- Cutting Edge Radiotherapy
- Innovation Still to Come
As our understanding of the genetics behind prostate cancer expands, it's possible that simple tests could reveal someone's risk of prostate cancer, meaning those at highest risk could benefit from more frequent screening. Professor Ros Eeles has been studying prostate cancer genetics at the ICR for more than 25 years. She has led research identify...
"Once we know who is more likely to benefit from screening, we can work to achieve early diagnosis. This is where a second revolutionary area of research becomes important: developing and using new types of diagnostic techniques. For example, liquid biopsies—simple blood tests aiming to identify changes specific to the tumor which can direct the cl...
Professor Johann De Bono has also been working on research involving a new 'search-and-destroy' medicine known as PSMA therapy. The treatment acts like a guided missile, consisting of a radioactive particle that can be delivered directly to cancer cells. The treatment, sometimes known as Lutetium-177 PSMA, uses a 'homing device' to seek out cancers...
Increasingly, we are moving away from a 'one-size-fits-all' approach to cancer care and we are getting better at tailoring treatment to individuals. The benefit of targeted treatments is that they involve fewer side effects and can help prostate cancer patients live longer but also with a better quality of life. In the next decade, we are hoping to...
It is thanks to well-conducted clinical trials that new cutting edge drugs eventually become available to patients. STAMPEDE, led by Professor Nick James, is an innovative multi-arm multi-stage (MAMS) trial which also helped change the standard of care for men with advanced prostate cancer. Three of the treatments tested have shown substantially im...
The immune system is able to kills cells that are harming the body, including cancer cells. However, cancer can often turn off the body's natural 'anti-cancer immune responses." One way in which our scientists are trying to defeat cancer is by reawakening the immune system, encouraging immune cells to attack cancer cells. Immunotherapy is a type of...
More and more evidence is showing that the microbiome—the community of microorganisms living in and on us, which are essential to our development and immunity—plays a role in many diseases, including prostate cancer. Recently, Professor de Bono and his team found that common gut bacteria can become 'hormone factories' and sustain prostate cancer's ...
There have also been many advances in the field of radiotherapy, including new courses of radiotherapy, known as 'hypofractionated radiotherapy," delivering higher doses of radiotherapy in fewer sessions. This supports a shorter treatment plan that allows men to finish treatment sooner—reducing the number of trips to hospital without negatively aff...
Professor de Bono shared his thoughts on the future: "The last decade has been historic for prostate cancer research, many advances have been made—we have started to use genetic information to personalize treatment, reduced side effects thanks to targeted therapies and we are just beginning to train the immune system to combat prostate cancer. "But...
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Apr 4, 2024 · Prostate cancer is the most common cancer in men in 112 countries, and accounts for 15% of cancers. In this Commission, we report projections of prostate cancer cases in 2040 on the basis of data for demographic changes worldwide and rising life expectancy.
Jul 12, 2021 · Men's Health. A new treatment for advanced prostate cancer improves survival in phase 3 clinical trial. July 12, 2021. By Charlie Schmidt, Editor, Harvard Medical School Annual Report on Prostate Diseases. Radiation therapy is getting more precise, enabled by technologies that make it easier to kill tumors while sparing their surrounding tissues.
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Jun 24, 2022 · Researchers have recommended changes to how cancer patients are treated, after a new UCL-led study discovered that chemotherapy is significantly more effective for some men with advanced prostate cancer than others.
