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Mar 26, 2020 · Patients who present with non-specific symptoms (or combinations of non-specific symptoms) that can indicate several different cancers currently don’t have an established effective referral pathway.
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- Study Selection
- Assessment of The Included Studies
- A. Patients Referred with NSSC
- B. The Patients Diagnosed with Cancer After Being Referred with NSSC
- Mental Health
- Socioeconomic Factors
- B. Patients Diagnosed with Cancer After Being Referred with NSSC
The literature search identified a total of 2751 publications which included 1394 duplicate publications for a total of 1357 original identified publications. A PRISMA flow diagram of the search is presented in Fig. 1. When applying the inclusion and exclusion criteria, 1303 publications were excluded, and 53 publications remained for full text ass...
Methodological quality
In the quality synthesis of the nine publications, information for the Newcastle–Ottawa Quality Assessment Scale (NOS) was extracted as shown in Table 2. All studies were cohort studies and were published from 2016 to 2022. The study populations ranged from 290 to 23,934 patients. Analysis of the methodological quality of the included articles was assessed using the NOS methods which categorises studies scoring as low quality (0–5 stars), medium quality, (6–7 stars) and high quality (8–9 star...
Patient characteristics and patient pathway
Eight included studies provided information about social and mental characteristics of participants [10, 12, 16, 17, 21, 23,24,25,26,27]. One study only included physical characteristics and another included physical characteristics and information about patient pathway [28, 29]. Nine publications held information about physical characteristics [10, 12, 16, 17, 21, 24,25,26,27,28]. Six of the ten included studies were from Denmark [12, 16, 17, 24,25,26,27,28,28] One was from Sweden, Two from...
The study population
The study population in the Netherlands study was defined by persons consulting their GP which led to the GP having any kind of gut feeling of cancer independent of clinical signs and symptoms . The study population of the studies from Denmark, the one from Sweden and the two from UK was defined by patients referred to a DC [10, 12, 16, 17, 21, 23,24,25,26,27,28,29]. The population of patients with NSSC were divided into two groups. The first group was made up of all patients referred wit...
Between 11 and 35% of all persons referred to a DC or who triggered GP gut feeling were later diagnosed with a cancer [10, 12, 16, 17, 21, 23,24,25,26,27,28,29]. The median number of days from referral to last visit day in DC was assessed in two studies from Denmark and ranged from 7 to 10 days [12, 16, 17, 24]. The Swedish study found that the med...
The 1-year mortality was between 28 and 44% for patients with a cancer diagnosed compared to 2–3% for patients who were not diagnosed with cancer after examination at DC [12, 16, 17]. One study showed that the median survival time after cancer diagnosis was 1,4 years . Two studies examined the stage of cancer and one showed that 47% of patients who...
Limited information about mental disorders was described in the studies. One study showed that 7% of the population had a mental illness diagnose when referred with non-specific symptoms of cancer [16, 17]. The same study showed that 2% of the population was diagnosed with a psychiatric disease after being referred with NSSC. Another study showed t...
Three studies showed that 54–68% of patients referred with NSSC were married/living with a partner and 31–32% were single/widowed/separated [10, 12, 16, 17, 24,25,26]. Two studies found that 28–37% of patients were employed when referred with NSSC, 1–7% were unemployed and 59–68% were retired [24–26]. One study showed that 81% of the population did...
Four studies showed that 40–58% of patients diagnosed with cancer were women and 42–60% men [12, 21, 24, 28]. Two studies study found that patients diagnosed with cancer had a significant higher age than those not diagnosed with cancer [21, 27]. Ingeman ML et. al . One study found that cancer were more often found in men than women, and another stu...
- Ellen Jensen
Feb 25, 2021 · We aimed to investigate the Non-specific Symptoms and Signs of Cancer-Cancer Patient Pathway (NSSC-CPP) in order to describe organisational and clinical practice similarities and differences in the diagnostic work-up of suspected cancer in Denmark.
- Christina Sadolin Damhus, Christina Sadolin Damhus, Volkert Siersma, Susanne Oksbjerg Dalton, John B...
- 10.1080/02813432.2021.1880094
- 2021
- Scand J Prim Health Care. 2021; 39(1): 23-30.
Jun 25, 2024 · While some symptoms are specific for certain cancers (e.g., breast lump for breast cancer and rectal bleeding for colorectal cancer) and suggest a clear diagnostic evaluation pathway, nonspecific signs and/or symptoms such as weight loss, anemia, fatigue, and pain could be associated with a range of cancer and noncancer diagnoses and therefore ...
The challenge facing primary care in diagnosing less common cancers presenting with non-specific symptoms is well documented. As an urgent referral pathway for non-specific symptoms, the MDC diagnosed a higher proportion of less common cancers than common cancers (n = 218 versus n = 155).
- Dave Chapman, Veronique Poirier, Karen Fitzgerald, Brian D. Nicholson, William Hamilton
- 2021
Dec 2, 2017 · No single non-specific symptom was significantly associated with a cancer diagnosis. Even organ-specific symptoms are known to have low predictive values of cancer making it unlikely for non-specific symptoms to be highly predictive.
The NSS cancer pathway is part of a national programme. It is designed to find the quickest, most efficient way to reach a diagnosis for patients who have non-specific symptoms. Your GP has found you have one or more non-specific symptoms. These symptoms are called “non-specific” as they affect the whole person. Symptoms can include:
