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  1. Samantha Who? is a sitcom about a woman who develops amnesia after a hit and run accident. The show ran on ABC from 2007 to 2009 and starred Christina Applegate, Jennifer Esposito, and Melissa McCarthy.

    • Sitcom
  2. Samantha Who? is a TV series that follows a woman who suffers from amnesia and tries to rediscover herself and her past. The series features Christina Applegate, Jennifer Esposito, Kevin Dunn and other stars, and won a Primetime Emmy in 2008.

    • (11K)
    • 2007-10-15
    • Comedy, Mystery, Romance
    • 22
  3. Watch the official Samantha Who? online at ABC.com. Get exclusive videos, blogs, photos, cast bios, free episodes

  4. Watch Samantha Who | Full episodes | Disney+. Samantha starts life over after waking up with amnesia.

  5. Samantha Who? is a comedy-drama series about a woman who suffers from retrograde amnesia and tries to rediscover her life. The episode list shows the titles, ratings, and summaries of each episode of the two seasons of the show.

  6. About. Samantha Newly has been a bad, bad girl. But thanks to an 8-day coma, she can't remember a thing. Not the parents she hasn't talked to in years. Not the boyfriend she's cheating on. And not the former friend she ditched in grade school. Fortunately her best friend Andrea is by her side with a cocktail and the 4-1-1 on every dirty deed.

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  8. Oct 14, 2007 · Samantha Newly, a self-centered real-estate executive, wakes up with amnesia after a hit-and-run accident and tries to be a better person. Watch episodes of this 2007 sitcom starring Christina Applegate on ABC.