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1. en.wikipedia.org › wiki › CD2CD2 - Wikipedia

   en.wikipedia.org › wiki › CD2

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   CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, [5] LFA-3 receptor, erythrocyte receptor and rosette receptor.

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3. www.ncbi.nlm.nih.gov › pmc › articlesCD2 Immunobiology - PMC - National Center for Biotechnology ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jun 9, 2020 · CD2 (green) is positioned in the T cell plasma membrane (light red) and locates to both the cSMAC and corolla. CD2 binds to lymphocyte-associated antigen 3 (LFA3; dark blue) which is located in the plasma membrane of the antigen-presenting cell (light blue). Among other molecules, TCR/pMHC and CD28/CD80/86 complexes also locate to the cSMAC.

   • DOI: 10.3389/fimmu.2020.01090
   • Published: 2020

   • Publication: Front Immunol. 2020; 11: 1090.

4. www.gettyimages.in › photos › cd258 Cd2 Stock Photos and High-res Pictures - Getty Images

   www.gettyimages.in › photos › cd2

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   Browse Getty Images’ premium collection of high-quality, authentic Cd2 stock photos, royalty-free images, and pictures. Cd2 stock photos are available in a variety of sizes and formats to fit your needs.

5. www.sciencedirect.com › topics › neuroscienceCD2 - an overview | ScienceDirect Topics

   www.sciencedirect.com › topics › neuroscience

   CD2 is a transmembrane molecule and a member of the immunoglobulin supergene family. CD2 plays an important role in T-cell activation, T- or NK-mediated cytolysis, apoptosis in activated peripheral T cells, and the production of cytokines by T cells. It is expressed by thymocytes, peripheral T cells, NK cells, and a subset of thymic B cells.

6. pubmed.ncbi.nlm.nih.gov › 32582179CD2 Immunobiology - PubMed

   pubmed.ncbi.nlm.nih.gov › 32582179

   Jun 9, 2020 · Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.

7. www.nature.com › articles › s41590/020/0770-xA dynamic CD2-rich compartment at the outer edge of the ...

   www.nature.com › articles › s41590/020/0770-x

   Sep 14, 2020 · The CD2–CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse, with...

8. People also ask

   Where is CD2 expressed in human thymocytes?

   • CD2 is expressed early during human thymocyte development and is found on about half of thymocytes and almost all mature peripheral T cells. In mice, CD2 is also expressed on some B cells and NK cells. CD2 functions as an intercellular adhesion molecule, binding with high affinity in humans to its ligand LFA-3 (CD58).

   CD2 - an overview | ScienceDirect Topics

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   What role does CD2 play in NK cell cytotoxicity?

   • Besides having an important role in NK cell conjugation to target cells (119), CD2 has been shown to recruit CD16 to the NK cell immunological synapse (NKIS) in spontaneous (antibody-independent) NK cell cytotoxicity.

   CD2 Immunobiology - PMC - National Center for Biotechnology Inform…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7295915/

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   Is CD2 a good target for memory T cells?

   • Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.

   CD2 Immunobiology | PubMed

   pubmed.ncbi.nlm.nih.gov/32582179/

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   What is the role of CD2 in T cells?

   • CD2 is a transmembrane molecule belonging to the immunoglobulin supergene family that plays a crucial role in T-cell activation, cytolysis, apoptosis, and cytokine production. It is expressed by thymic T-cells, peripheral T-cells, NK cells, and a subset of thymic B-cells, serving as a pan-T-cell marker.

   CD2 - an overview | ScienceDirect Topics

   www.sciencedirect.com/topics/neuroscience/cd2

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9. www.sciencedirect.com › cd2CD2 - an overview | ScienceDirect Topics

   www.sciencedirect.com › cd2

   CD2AP. CD2-associated protein (CD2AP) is a modular cytoplasmic docking protein that interacts with multiple slit diaphragm components, including nephrin and podocin, as well as with the actin cytoskeleton (Fig. 5) (158, 164).