Search results
Apr 3, 2024 · The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O (6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions.
Methylated-DNA--protein-cysteine methyltransferase (MGMT), also known as O 6-alkylguanine DNA alkyltransferase AGT, is a protein that in humans is encoded by the MGMT gene. MGMT is crucial for genome stability.
Apr 22, 2024 · O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that removes the guanine-alkyl group induced by alkylating agents such as temozolomide. The meta-analysis indicated the association between MGMT promoter hypermethylation and squamous intraepithelial lesion and cervical cancer.
Jan 17, 2020 · O 6 -methylguanine-DNA methyltransferase, known as MGMT, is a DNA “suicide” repair enzyme. It repairs damaged guanine nucleotides by transferring the methyl at O 6 site of guanine to its cysteine residues, thus avoiding gene mutation, cell death and tumorigenesis caused by alkylating agents.
While O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation status is accepted as a prognostic and promising predictive biomarker in glioblastoma, its value in informing treatment decisions for glioblastoma patients is still debatable.
Mar 10, 2005 · Epigenetic silencing of the MGMT (O 6 -methylguanine–DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival...
Apr 1, 2004 · MGMT is a DNA-repair gene. MGMT has been studied for over 20 years as a gene that is associated with methylating-agent resistance in both prokaryotes 21 and in human cells 22.
Jan 1, 2012 · O 6 -methylguanine-DNA methyltransferase (MGMT, also called O 6 -alkylguanine-DNA alkyltransferase) protects the cellular genome from the mutagenic actions of endogenous carcinogens and clinically active alkylating agents.
Feb 1, 2003 · Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.
O(6)-Methylguanine-DNA-methyltransferase (MGMT) is a unique protein, which both repairs O(6)-alkylguanine lesions stoichiometrically without a multi-enzymatic pathway and self-inactivates. It has recently been linked to the therapeutic success of alkylating agent chemotherapy, specifically temozolom …
