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  1. DATING BY LMP AND BIOMETRIES.

  2. Calculate fetal weight, biometries, doppler and uterine arteries based on gestational age and ultrasound data. Use the reference values adapted to the population of Vall d'Hebron Hospital.

    • Clinical Application
    • Measurement of Biomarkers
    • Audit of Results
    • GeneratedCaptionsTabForHeroSec

    Screening for PE at 11-14 weeks 1

    1. The objective of screening at this stage is the identification of a group at high-risk for preterm-PE (<37 weeks) and the reduction of such risk through the prophylactic use of aspirin (150 mg/day from 11-14 to 36 weeks). The ASPRE trial has shown that in pregnancies at high-risk for PE administration of aspirin reduces the rate of early-PE (<32 weeks) by about 90% and preterm-PE by 60%. Prophylactic use of aspirin does not reduce the incidence of term-PE 2. 2. Combined screening by matern...

    Screening for PE at 19-25 weeks 3

    Screening at this stage should ideally be by a combination of maternal factors, uterine artery PI, mean arterial pressure and serum PLGF and the risk for PE <32 weeks and PE <36 weeks should be calculated. On the basis of these risks the women are stratified into high-, intermediate- and low-risk management groups. The high-risk group would require close monitoring for high blood pressure and proteinuria at 24-31 weeks. The intermediate-risk group together with the undelivered pregnancies fro...

    Screening for PE at 30-35 weeks

    Screening at this stage should ideally be by a combination of maternal factors, uterine artery PI, mean arterial pressure, serum PLGF and serum sFLT-1. 1. At risk cut-off of 1 in 150 for PE <36 weeks, 10% of the population would be stratified into the high-risk group which will contain nearly all cases that will develop PE at 32-36 weeks; these patients need close monitoring for high blood pressure and proteinuria at 32-35 weeks. 2. All pregnancies would have reassessment of risk for PE at 35...

    Technique for measurement of mean arterial pressure: please
    Technique for measurement of uterine artery PI: please UTPI can be measured by either transabdominal or transvaginal sonography.
    Measurement of biochemical markers requires validated equipment and reagents. At present these are provided by DelfiaXpress from PerkinElmer, Kryptor from ThermoFisher and Elecsys from Roche.
    All measurements for biophysical and biochemical markers are expressed as multiples of the normal median (MoMs), adjusting for maternal factors that provide substantive contribution to their value....

    To ensure that the service you provide is of high quality it is important that you audit the distribution of your mean arterial pressure and uterine artery PI measurements and MoM values of PAPP-A, PLGF and sFLT-1 at regular intervals. 1. To audit the distribution of mean arterial pressure measurements please click here. 2. To audit the distributio...

    This web page provides a tool to estimate the risk of preeclampsia based on maternal factors and biomarkers at different stages of pregnancy. It also gives guidance on screening, management and audit of preeclampsia.

  3. Use this tool to plot the Doppler indices of your patient on the normal range chart. Enter the gestational age and the values of middle cerebral artery, uterine artery, umbilical artery and ductus venosus PI.

  4. This application allows estimation of risks for trisomies 21, 18 and 13 at 11-13 weeks’ gestation by a combination of maternal age, fetal nuchal translucency thickness, fetal heart rate and maternal serum free ß-hCG and PAPP-A.

  5. Calculate the z-score, centile, median and centiles of umbilical artery, middle cerebral artery and cerebroplacental ratio based on fetal Doppler studies. The data is derived from routine second and third trimester screening studies conducted by the FMF.

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  7. Measurement of mean arterial pressure (MAP) is useful in the prediction of preeclampsia risk in early pregnancy. Enter your blood pressure and weight to calculate your MAP and compare it with the 90th centile.