Search results
A mast cell (also known as a mastocyte or a labrocyte [1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
Learn about mast cells, a type of white blood cell that releases histamine and other substances in response to stimuli. Find out where mast cells are located, how they activate and degranulate, and what role they play in inflammation and allergies.
Mast cells are tissue-resident cells that can respond to various stimuli and release inflammatory mediators. Learn about their development, location, function and effects of mast cell activation in this bite-sized immunology article.
Jan 6, 2016 · Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings.
- Melissa Krystel-Whittemore, Kottarappat N. Dileepan, John G. Wood
- 10.3389/fimmu.2015.00620
- 2016
- Front Immunol. 2015; 6: 620.
May 16, 2024 · Mast cells act like an alert system. They protect your body from foreign invaders (pathogens like viruses, bacteria and parasites) and toxins (for instance, venom from snake bites or bee stings). They also fight off particles they think are harmful, even when they’re not. This causes allergic reactions.
May 1, 2023 · Mast cells are immune cells derived from the myeloid lineage. After arising in the bone marrow, progenitor cells circulate and become home to various tissues. Under the influence of stem cell factors locally produced by many cells in the tissue, the progenitor differentiates into a mature mast cell.
Mast cells, at least in the human, develop from CD34 + /CD117 + pluripotent progenitor cells originating in the bone marrow. 1 The progression of these cells to
