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Features of Orphan Annie-eye nuclei in histopathology include, large nuclei, oval/molded with singular membranes, nuclear clearing with powdery chromatin, nuclear grooves, one/more marginally placed micro nucleoli, nuclear crowding with optically clear ground glass appearance, and nuclei that are often seen overlapping on each other. [3, 4]
- Radhika M Bavle
- 10.4103/0973-029X.119737
- 2013
- May-Aug 2013
Papillary thyroid carcinoma has a number of unique morphologic features. I mentioned psammoma bodies a few days ago. Illustrated above is another characteristic feature: Orphan Annie nuclei. These are so named because they have a "cleared-out" appearance, similar to Little Orphan Annie's eyes.
In this review, we will provide a detailed description of the histological features of papillary thyroid carcinoma, including characteristic histologic features such as "Orphan Annie eye" nuclei and psammoma bodies.
Characteristic Orphan Annie eye nuclear clearings (nuclei with uniform staining, which appear empty due to powdery chromatin and marginal micronucleoli) [12] and psammoma bodies on light microscopy. The former is useful in identifying the follicular variant of papillary thyroid carcinomas. [13]
Sep 1, 2016 · The presence of orphan annie-eye nuclei is a significant feature for the diagnosis of papillary thyroid carcinoma (PTC), a cancer of the thyroid gland. Automated detection and segmentation of orphan annie-eye nuclei from histopathology imagery is an intricate procedure due to traditional and specific challenges.
- J. Angel Arul Jothi, V. Mary Anita Rajam
- 2016
Jul 1, 1988 · Ground glass nuclei and Orphan Annie Eye nuclei are currently accepted as the most useful signs for the diagnosis of papillary carcinoma of the thyroid. The nuclear appearance, however, is not used in transoperative studies because the general opinion is that they are only found in permanent section …
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Jan 7, 2022 · Inherited retinal diseases (IRDs) are a heterogenous group of orphan eye diseases that typically result from monogenic mutations and are considered attractive targets for gene-based therapeutics.
