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The core of PANTHER is a comprehensive, annotated “library” of gene family phylogenetic trees. All nodes in the tree have persistent identifiers that are maintained between versions of PANTHER, providing a stable substrate for annotations of protein properties like subfamily and function.
The mission of the PANTHER knowledgebase is to support biomedical and other research by providing comprehensive information about the evolution of protein-coding gene families , particularly protein phylogeny, function and genetic variation impacting that function.
PANTHER (Protein Analysis Through Evolutionary Relationships) is an integrated knowledgebase of evolutionary and functional relationships between protein-coding genes (1) (referred to hereafter as proteins), as well as tools for using the classifications to analyze large-scale genomics data (2, 3).
Jul 18, 2013 · The PANTHER (protein annotation through evolutionary relationship) classification system (http://www.pantherdb.org/) is a comprehensive system that combines gene function, ontology, pathways and...
Jan 1, 2003 · The current version of the PANTHER database includes training sequences from all organisms in the GenBank non-redundant protein database, and the HMMs have been used to classify gene products across the entire genomes of human, and Drosophila melanogaster.
Jan 1, 2005 · PANTHER is quite comprehensive for the annotation of protein sequences encoded by metazoan genomes: ∼90% of mammalian protein-coding genes, and nearly two-thirds of Drosophila genes, are hit by a PANTHER HMM. The PANTHER database has recently been expanded to include associations between protein sequences and the biological pathways they ...
