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Methylated-DNA--protein-cysteine methyltransferase
mdpi.com
- Methylated-DNA--protein-cysteine methyltransferase (MGMT), also known as O6-alkylguanine DNA alkyltransferase AGT, is a protein that in humans is encoded by the MGMT gene. MGMT is crucial for genome stability.
en.wikipedia.org/wiki/Methylated-DNA-protein-cysteine_methyltransferaseMethylated-DNA-protein-cysteine methyltransferase - Wikipedia
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Methylated-DNA--protein-cysteine methyltransferase (MGMT), also known as O 6-alkylguanine DNA alkyltransferase AGT, is a protein that in humans is encoded by the MGMT gene. MGMT is crucial for genome stability.
Apr 3, 2024 · The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O (6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions.
O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that removes the guanine-alkyl group induced by alkylating agents such as temozolomide. The meta-analysis indicated the association between MGMT promoter hypermethylation and squamous intraepithelial lesion and cervical cancer.
Jan 17, 2020 · O 6 -methylguanine-DNA methyltransferase, known as MGMT, is a DNA “suicide” repair enzyme. It repairs damaged guanine nucleotides by transferring the methyl at O 6 site of guanine to its cysteine residues, thus avoiding gene mutation, cell death and tumorigenesis caused by alkylating agents.
- Wei Yu, Lili Zhang, Qichun Wei, Anwen Shao
- 10.3389/fonc.2019.01547
- 2020
- Front Oncol. 2019; 9: 1547.
While O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation status is accepted as a prognostic and promising predictive biomarker in glioblastoma, its value in informing treatment decisions for glioblastoma patients is still debatable.
- Madison Butler, Lorinc Pongor, Yu-Ting Su, Liqiang Xi, Mark Raffeld, Martha Quezado, Jane Trepel, Ke...
- 10.1016/j.trecan.2020.02.010
- 2020
- 2020/05
Apr 1, 2004 · MGMT is a DNA-repair gene. MGMT has been studied for over 20 years as a gene that is associated with methylating-agent resistance in both prokaryotes 21 and in human cells 22.
O6 -Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the pre-mutagenic, pre-carcinogenic and pre-toxic DNA damage O6 -methylguanine. It also repairs larger adducts on the O6 -position of guanine, such as O (6)- [4-oxo-4- (3-pyridyl)butyl]guanine and O6 -chloroethylguanine.
