Search results
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
InterPro is a bioinformatics resource that provides functional analysis of protein sequences by classifying them into families and predicting the presence of domains and important sites (Figure 1).
InterPro combines protein signatures from multiple, diverse databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool for protein sequence classification.
Search for a domain architecture, for entries related to a Pfam model; Browse through InterPro entries, member databases, proteins, structures, taxonomy, proteomes or clan/sets. Figure 2 highlights the location of the different search entry points on the InterPro web interface.
explain what InterPro is and how it can help you to relate protein architecture to function; determine where to find out more about InterPro
InterPro2GO mapping. InterPro is an integrated resource of protein families, domains and sites which are combined from a number of different protein signature databases, including. Gene3D, Panther, PRSF, Pfam, PRINTS, ProSite, ProDom, SMART, SUPERFAMILY and TIGRFAMs.
You can find the InterPro site at http://www.ebi.ac.uk/interpro/ or by clicking on the InterPro link on the EBI home page. However, for this tutorial we will use the
Sequence searching. To search InterPro with one or multiple protein sequence (s), copy and paste the amino acid sequence (s) into the large box, or upload a fasta file on the home page and click on the search button located below the box (Figure 10).
When to use InterPro. You can use InterPro if you have an amino acid sequence or set of sequences and you want to know: what they are – the family to which they belong. what their function is and how it can be explained in structural terms.
InterPro entries are classified into one of five categories, depending on the biological entity they represent: homologous superfamily, protein family, domain, repeat or site. The entry type is indicated by a specific icon (Figure 4), which can be found on the top left hand side of an InterPro entry page .
