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The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene functions and gene products across different databases. The GO knowledgebase is composed of three primary components: 1. Gene Ontology, which provides the logical structure of the biological functions (‘terms’).
Gene ontology. Gene Ontology (GO) is one of the main resources of biological information since it provides a specific definition of protein functions. GO is a structured and controlled vocabulary of terms, called GO terms.
Jan 1, 2022 · Gene Ontology Functional Enrichment Annotation Tool. GO-FEAT (Gene Ontology Functional Enrichment Annotation Tool) is a freely available, user-friendly, easily customizable web server and emerging as an integrated tool to analyze functional annotations and enrichment of transcriptome sequence data.
Jan 1, 2022 · Gene Ontology (GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were applied for the identification of key genes and pathways involved in EOC. We identified 1091 Differential Expression Genes (DEGs) which have been reported in various studies of ovarian cancer as well as other types of cancer.
Dec 1, 2023 · In this study, we proposed a novel method based on Gene Ontology (GO) to predict the localization of the submitochondrial proteins, called GO-Submito. More specifically, the GO-Submito fine-tuned pre-training Bidirectional Encoder Representations from Transformers models to encode GO annotations into vectors.
May 1, 2023 · Besides the KEGG enrichment scores, this study further adopted gene ontology (GO) enrichment scores and STRING confidence scores to represent each protein. A systemic computational analysis, including feature selection methods and classification algorithms, was applied to investigate these features. Some essential features were obtained.
Nov 1, 2021 · The Gene Ontology (GO) provides a rigorously defined set of concepts that describe the functions of gene products. •. GO annotations link a gene product and a GO concept, and are supported by scientific evidence. •. Transcription plays a central role in defining the identity and functionalities of cells, is mediated by large complexes. •.
Aug 28, 2021 · Although many tools have been developed for gene-centric or epigenomic enrichment analysis, most are designed for model organisms or specific domains (e.g., fungi, 2 plants 3) embedded with particular annotations such as Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). 4 Non-model organisms and functional annotations other than GO and KEGG are poorly supported. Moreover, the increasing concerns for the quality of gene annotation have raised an alarm in biomedical ...
Mar 1, 2020 · Diversity in physiochemical properties, structure and gene ontology were observed among LEA3, LEA4 and LEA6 domain-containing proteins along with their genomic distribution and level of expression. An inverse relationship between disorder and coil content, while a direct relationship between disorder and helix content were observed in these LEA domain-containing proteins.
May 1, 2019 · Gene Ontology (GO), a leading community effort project, was initiated to support computational gene function prediction and to organize biological knowledge of genes and their products in a formal and consistent way across genomic resources [14, 15]. GO provides a framework and set of concepts (or terms) to describe the functions of gene products from all organisms.
