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Congo red stain is the gold standard for the demonstration of amyloid in tissue sections. Used to evaluate the presence and extent of amyloidosis in different organs. Common diseases for Congo red stain include primary amyloidosis, amyloid light chain (AL) seen in plasma cell dyscrasias, amyloid A (AA) associated with inflammatory conditions.
Congo red: ordinary light imparts a pink to red color to amyloid deposits; the beta pleated sheet structure of amyloid produces an apple green birefringence under polarized microscopy when stained by Congo red or sirius red stain PAS: moderately positive
Oct 16, 2024 · Essential features. Diabetic kidney disease is a morphological structural change in the glomeruli that occurs due to longstanding hyperglycemia (Contrib Nephrol 2011;170:36) Characterized by mesangial matrix expansion and diffuse thickening of glomerular, tubular and Bowman capsule basement membranes. Mesangial matrix expansion can be diffuse ...
Sep 27, 2023 · M protein in serum (IgG or IgA) at ≥ 3 g/dL. Or Bence Jones protein ≥ 500 mg/24 h urine. Or 10 - 59% clonal plasma cells in bone marrow. And no related tissue damage / myeloma defining event or amyloidosis; if bone survey negative, bone disease should be assessed with whole body MRI, FDG PET / CT or low dose CT scan.
Comment: The submucosa adjacent to tubular adenoma contains prominent hyalinized, homogenously eosinophilic, amorphous ribbons and globules with foreign body giant cells, scattered eosinophils and fibrosis consistent with lifting agent granuloma. Congo red stain is negative for amyloid. (Am J Surg Pathol 2020;44:793)
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A cardiac biopsy demonstrates negative Congo red staining and there is a well founded morphologic suspicion for cardiac amyloidosis. What is the next best step? Abdominal fat pad biopsy Crystal violet stain Provide the negative diagnosis and suggest alternative diagnoses Repeat Congo red stain on 2 more sections
Oct 1, 2016 · Abnormal deposition of insoluble protein in an abnormal fibrillary configuration. Most common types are amyloid light chain (AL) and amyloid A (AA) AL is caused by immunoglobin light chains and is secondary to plasma cell dyscrasia. AA is reactive amyloidosis and is secondary to chronic inflammatory disease. In vast majority of patients, breast ...
Jul 1, 2016 · Ancillary studies show the epithelial cells of CEOT highlight with cytokeratin AE1/3, CK5/6 and p63, and amyloid-like material exhibits apple green birefringence when stained with Congo red and viewed with polarized light Sclerosing odontogenic carcinoma. Rare and controversial entity, described in 2008
Apr 14, 2022 · Congo red stain is positive (AL or AH amyloid diagnosis) or negative (nonamyloid MGRS diagnosis). The findings are consistent with the patient's documented history of X (if patient has a known diagnosis of hematolymphoid neoplasm) or clinical correlation with appropriate hematologic studies is recommended (if there is no known hematolymphoid diagnosis).
