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Why is HER2 a human gene?
Is HER2 a ligand?
What is the structure of the HER2–HER3 Fab complex?
Why is HER2 called HER1?
Feb 13, 2023 · 16 Citations. 11 Altmetric. Metrics. Abstract. HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its overexpression or hyperactivation is a leading cause for...
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HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor.
HER2 is a membrane tyrosine kinase and oncogene that is overexpressed and gene amplified in about 20% of breast cancers. When activated it provides the cell with potent proliferative and anti-apoptosis signals and it is the major driver of tumor development and progression for this subset of breast cancer.
- Carolina Gutierrez, Rachel Schiff
- 10.1043/2010-0454-RAR.1
- 2011
- 2011/01
Feb 13, 2003 · Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 2003 Feb 13;421 (6924):756-60. doi: 10.1038/nature01392. Authors. Hyun-Soo Cho 1 , Karen Mason , Kasra X Ramyar , Ann Marie Stanley , Sandra B Gabelli , Dan W Denney Jr , Daniel J Leahy. Affiliation.
- Hyun Soo Cho, Karen Mason, Kasra X. Ramyar, Ann Marie Stanley, Sandra B. Gabelli, Dan W. Denney, Dan...
- 2003
Nov 10, 2021 · Our structure of the HER2 (S310F)–HER3–NRG1β–trastuzumab Fab complex reveals that the receptor dimer undergoes a conformational change to accommodate trastuzumab. Thus, similar to...
- Devan Diwanji, Raphael Trenker, Tarjani M. Thaker, Tarjani M. Thaker, Feng Wang, David A. Agard, Kli...
- 2021
Summary. Human epidermal growth factor receptors (HER/ erb B) constitute a family of four cell surface receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the HER2 receptor.
This human gene encodes a protein that has a structure consistent with a growth factor receptor and has been designated HER2, due to its similarity to the human epidermal growth factor receptor [2, 3]. The HER2 receptor has an important role in normal cell growth and differentiation.
