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Mar 13, 2019 · A highly site-selective aromatic C–H functionalization reaction that does not require a particular directing group or arene substitution pattern provides functionalized arenes that can...
- Nature
We would like to show you a description here but the site...
- Remote site-selective arene C–H functionalization enabled by ...
Catalytic site-selective functionalization of distal C–H...
- Organocatalyst-controlled site-selective arene C–H ... - Nature
Now, an organocatalyst-controlled site-selective C–H...
- Nature
Dec 5, 2017 · Similarly the well-known Barton nitrite reaction permits the site-selective C(sp 3)–H functionalization of saturated alcohols, in which the thermodynamic capability of alkoxy radicals to abstract hydrogen from alkyl C–H bonds at the δ-position is controlled by an entropically favorable intramolecular S H 2 process.
- Davide Ravelli, Maurizio Fagnoni, Takahide Fukuyama, Tomohiro Nishikawa, Ilhyong Ryu, Ilhyong Ryu
- 2018
Jul 11, 2024 · Catalytic site-selective functionalization of distal C–H bonds represents a formidable challenge in organic synthesis. Particularly, the precise functionalization of distal aromatic...
Feb 14, 2022 · Achieving site-selective C-H functionalization of arene is a fundamental challenge, as it is mainly controlled by the electronic nature of the mols. A chelation-assisted C-H functionalization strategy overcomes the selectivity issues by utilizing distance and geometry of covalently attached directing groups (DGs).
Aug 9, 2021 · Now, an organocatalyst-controlled site-selective C–H functionalization of arenes has been developed, with wide substrate generality and applicability, offering a general strategy for...
- Jian-Hui Mao, Yong-Bin Wang, Limin Yang, Shao-Hua Xiang, Quan-Hao Wu, Yuan Cui, Qian Lu, Jie Lv, Sha...
- 2021
Jan 11, 2024 · Billions of years of evolution have honed nature’s extraordinary capacity in promoting site-selective functionalization of C(sp 3)–H bonds in complex molecules. Central to this incredible proficiency is the effect of confinement incurred by enzymes’ active sites, which pre-organize substrates in desired co-conformations prior to their ...
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What is site selective C–H functionalization?
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Feb 14, 2019 · Site-Selective C–H Functionalization Incorporates the Anions of Acids, Salts, and Acyl Halides (A) Aryl C–H functionalization with acids, HX. (B) Aryl C–H chlorination with chlorides, MCl or RCl. (C) Heteroarene C–H chlorination with acyl chlorides, RCl.
