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  1. www.ed.ac.uk › profile › professor-siddharthan-chandranProfessor Siddharthan Chandran - The University of Edinburgh

    Jun 18, 2024 · Professor Chandran is a neurologist, neuroscientist and academic leader at the University of Edinburgh. He is the Dean of Clinical Medicine, Head of Edinburgh Medical School, Director of Edinburgh Neuroscience and several research centres, and a Fellow of the Academy of Medical Sciences.

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  3. ukdri.ac.uk › team › siddharthan-chandranSiddharthan Chandran - UK DRI: UK Dementia Research Institute

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    Dissecting a genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) Amyotrophic lateral sclerosis (ALS, also known as motor neurone disease (MND)) and frontotemporal dementia (FTD) are neurodegenerative diseases, which emerging evidence shows may have significant overlap in biological cause. Although most people who ...

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    The overall objective of this UK DRI programme, led by Prof Siddharthan Chandran, is to better understand glial-neuronal cross talk and how this is altered in neurodegenerative disorders, using patient-derived mutant C9orf72iPS cell lines as a prototypic example, and determining whether manipulating axo-glial interaction is neuroprotective. The C9o...

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    Dr Karen Burr (Project Officer) Dr David Hampton (Academic) Dr Poulomi Banerjee (Postdoctoral Researcher) Dr Roderick Carter (Postdoctoral Researcher) Dr Marcus Keatinge (Postdoctoral Researcher) Dr Vidya Ramesh (Postdoctoral Researcher) Dr Arpan Mehta (Postdoctoral Researcher) Dr Nhan Pham (Postdoctoral Researcher) Dr Paul Baxter (Postdoctoral Res...

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    Within UK DRI: 1. Prof Giles Hardingham, UK DRI at Edinburgh 2. Prof Chris Shaw, UK DRI at King's 3. Prof Tara Spires-Jones, UK DRI at Edinburgh 4. Prof Dario Alessi, UK DRI Associate Member, MRC PPU, University of Dundee 5. Prof Josef Priller, UK DRI at Edinburgh 6. Prof Adrian Isaacs UK DRI at UCL Beyond UK DRI: 1. Prof Colin Smith, University of...

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    C9orf72 gene, frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), triplet repeat expansions, glial cells

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    Banerjee P, Mehta AR, Nirujogi RS, Cooper J, James OG, Nanda J, Longden J, Burr K, McDade K, Salzinger A, Paza E, Newton J, Story D, Pal S, Smith C, Alessi DR, Selvaraj BT, Priller J, Chandran S. Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration. Sci Adv. 2023 Apr...

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    Prof Siddharthan Chandran is a leading expert in neurodegenerative diseases and Regenerative Neurology. He studies the genetic cause of ALS and FTD using patient-derived stem cells and chimeric transplants.

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  4. www.research.ed.ac.uk › siddharthan-chandranSiddharthan Chandran - University of Edinburgh Research Explorer

    Professor Siddharthan Chandran works in the emerging discipline of Regenerative Neurology. His research combines laboratory activity that includes human stem cells with specialist clinics (multiple sclerosis [MS] and motor neurone disease [MND]) to both study disease as well as undertake early-phase clinical trials.

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  6. www.ucl.ac.uk › brain-sciences › newsProfessor Siddharthan Chandran appointed new Director of the ...

    Jun 14, 2023 · Professor Chandran, a clinician-scientist and expert in regenerative neurology, will take over as Director of the UK DRI from October 2023. The UK DRI is the single biggest investment in dementia research in the UK, with a centre based at UCL Queen Square Institute of Neurology.

  7. scholar.google.com › citations‪Siddharthan Chandran‬ - ‪Google Scholar‬

    Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic …. A Wilkins, H...

  8. ukmndri.org › team › siddharthan-chandranSiddharthan Chandran - UKMNDRI

    Siddharthan Chandran is a Professor of Neurology and Regenerative Medicine at the University of Edinburgh. He leads the UK Dementia Research Institute and the Euan MacDonald Centre for Motor Neuron Disease Research.

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  10. ukdri.ac.uk › news-and-events › professorProfessor Siddharthan Chandran appointed as new Director of ...

    Jun 14, 2023 · Prof Siddharthan Chandran is a clinician-scientist and a Group Leader at the UK DRI at Edinburgh. He will become the new Director of the UK DRI from 1 October 2023, leading the Institute's vision to transform the outlook for people with dementia and related conditions.