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- In humans, tissue kallikreins (hK) are encoded by 15 structurally similar, steroid hormone–regulated genes (KLK) that colocalize to chromosome 19q13.4, representing the largest cluster of contiguous protease genes in the entire genome. hKs are widely expressed in diverse tissues and implicated in a range of normal physiologic functions from the regulation of blood pressure and electrolyte balance to tissue remodeling, prohormone processing, neural plasticity, and skin desquamation.
People also ask
Are kallikreins biochemical?
Why are kallikreins important?
Is kallikrein a kinin?
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (encoded by KLKB1 gene) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases.
The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles.
- Magdalena Kalinska, Ulf Meyer-Hoffert, Tomasz Kantyka, Jan Potempa, Jan Potempa
- 10.1016/j.biochi.2015.09.023
- 2016
- 2016/03
Nov 21, 2019 · Dysregulation of KLK expression is associated with many inflammatory diseases and cancer types. Specifically for skin, abnormal activation of the KLK proteolytic cascade is reported in Netherton syndrome (NS), atopic dermatitis (AD) and psoriasis highlighting pro-inflammatory roles of KLKs.
- Pauline Nauroy, Alexander Nyström
- 10.1016/j.mbplus.2019.100019
- 2020
- Matrix Biol Plus. 2020 May; 6-7: 100019.
May 1, 2004 · In humans, tissue kallikreins (hK) are encoded by 15 structurally similar, steroid hormone–regulated genes (KLK) that colocalize to chromosome 19q13.4, representing the largest cluster of contiguous protease genes in the entire genome. hKs are widely expressed in diverse tissues and implicated in a range of normal physiologic functions from ...
Aug 30, 2023 · Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight kininogens (HKs and LKs) as substrates, releasing bradykinin (Bk) and Lys-bradykinin (Lys-Bk), ...
- 10.3389/fphys.2023.1188816
- 2023
- Front Physiol. 2023; 14: 1188816.
In this review, we summarize available information about kallikreins in many animal species with special emphasis on human kallikreins. We discuss the common structural features of kallikreins at the DNA, mRNA and protein levels and overview their evolutionary history.
The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles.
