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Is NSIP a separate entity in pulmonary fibrosis?
What is the difference between NSIP and UIP?
Which features favor the diagnosis of NSIP vs UIP?
What is nonspecific interstitial pneumonia (NSIP)?
3 days ago · Several key features can help to distinguish NSIP from UIP. While helpful, the differences between UIP and NSIP are often not as obvious as this figure suggests, and the difficulty lies in distinguishing the cases that lie toward the middle.
- Chronic Hp Mimicking NSIP
As previously discussed, it is often difficult to...
- Indeterminate for UIP Pattern
Differentiating UIP and NSIP; Cryptogenic Organizing...
- Chronic Hp Mimicking NSIP
- Epidemiology
- Clinical Presentation
- Pathology
- Radiographic Features
- Treatment and Prognosis
- Differential Diagnosis
- Practical Points
Non-specific interstitial pneumonia typically tends to present in middle-aged adults 40-50 years of age 1. It may be more common in the White-European population 9. The overall prevalence is higher in women due to an association with collagen vascular disease, but the prevalence of idiopathic NSIP is similar in both genders. NSIP is associated with...
The symptoms of non-specific interstitial pneumonia include insidious onset of dyspnea and dry cough with a restrictivepattern of decreased lung function and reduced gas exchange capacity.
Temporal and spatial homogeneity in a specimen is an essential feature. Historically, non-specific interstitial pneumonia was divided into three groups; however, due to similar outcomes, groups II and III (mixed cellular and fibrotic and mostly fibrotic, respectively) are now both classified as fibrotic type: 1. fibrotic non-specific interstitial p...
A chest radiograph can be normal in the early stages. There may be ill-defined or ground-glassopacities with lower lobe distribution or consolidation in a patchy, reticulonodular or mixed pattern. A bilateral pulmonary infiltrative pattern with volume loss of lower lobes may be seen in those with advanced disease. Fibrotic NSIP maximally and symmet...
In general, non-specific interstitial pneumonia (NSIP) carries a much more favorable prognosis than a usual interstitial pneumonia (UIP) pattern, with a 90% 5-year survival rate for the cellular subtype and a ~60% (range 45-90%) 5-year survival for the fibrotic subtype. Cellular NSIP shows a better response to corticosteroids and carries a substant...
The key differential is the usual interstitial pneumonia (UIP) pattern, with which there can be some overlap in imaging features 3. The features that favor the diagnosis of NSIP over UIP are symmetrical bilateral ground-glass opacities with fine reticulations and sparing of the immediate subpleural space. The presence of macrocystic honeycombingis ...
Examination of prior scans is essential to correct categorization of the CT pattern. CTD-ILD may display features which suggest the diagnosis including esophageal dilatation, serositis, joint erosions or muscle atrophy.
Feb 25, 2021 · Prone imaging confirms these possible abnormalities as true disease or not and can also facilitate detection of specific signs such as honeycombing in usual interstitial pneumonia (UIP) or subpleural sparing in nonspecific interstitial pneumonia (NSIP).
- Stephen Hobbs, Jonathan H Chung, Jay Leb, Kate Kaproth-Joslin, David A Lynch
- 2021
IPF/UIP and NSIP closely mimic each other clinically but NSIP has a far better outcome. However, it remains unclear if NSIP is a truly separate and distinct entity. The histopathological pattern of NSIP can be found in a wide variety of clinical and radiological contexts.
- Roland du Bois, Talmadge E King
- 2007
Aug 14, 2023 · Fibroblastic foci and peripheral accentuation are typically absent, which helps to differentiate it from usual interstitial pneumonia (UIP). NSIP is also characterized by diffuse alveolar wall thickening by uniform fibrosis, but with the preservation of the alveolar architecture.
- Ali S. Nayfeh, Venu Chippa, Douglas R. Moore
- 2023/08/14
- 2019
Dec 12, 2005 · Of these disorders, the two entities that have provoked most discussion and debate are idiopathic pulmonary fibrosis (IPF; as currently defined with a usual interstitial pneumonia (UIP) pattern of pathology) and non‐specific interstitial pneumonia (NSIP).
Sep 12, 2018 · A first approach is to separate the eight pathologically defined patterns into six major (UIP, NSIP, COP, DIP, RB-ILD, AIP) and two rare or less commonly encountered entities (LIP and PPFE). Of the six major patterns, a review of their courses and presentations as well as associated clinical findings further leads to three subcategorizations:
