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Nov 16, 2019 · In a multicenter trial, we randomly assigned 145 asymptomatic patients with very severe aortic stenosis (defined as an aortic-valve area of ≤0.75 cm 2 with either an aortic jet velocity of ≥4. ...
- Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis
The poor outcome of patients with symptomatic aortic...
- Transcatheter Aortic-Valve Replacement for Asymptomatic ...
For patients with asymptomatic severe aortic stenosis and...
- Transcatheter or Surgical Treatment of Aortic-Valve Stenosis
Methods. In this randomized noninferiority trial conducted...
- Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis
Nov 13, 2021 · The AVATAR trial (Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis) is an investigator-initiated international prospective randomized controlled trial that evaluated the safety and efficacy of early SAVR in the treatment of asymptomatic patients with severe AS, according to common criteria (valve area ≤1 cm 2 with aortic jet velocity >4 m/s or a mean transaortic gradient ≥40 mm Hg), and with normal left ventricular function.
- Marko Banovic, Svetozar Putnik, Martin Penicka, Gheorghe Doros, Marek A. Deja, Radka Kockova, Martin...
- 2021
Oct 28, 2024 · For patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction, current guidelines recommend routine clinical surveillance every 6 to 12 months. Data from ra...
Oct 28, 2024 · These patients had critical aortic stenosis with a mean aortic valve peak velocity of more than 5 m/s, meaning most would have met the Class IIb level recommendation for aortic valve intervention at trial inclusion. 2,3,6 The AVATAR trial demonstrated a long-term benefit in all-cause, but not cardiovascular, mortality, but also recruited a younger patient population that included patients with very severe aortic stenosis. Even after enriching for a high-risk population with myocardial ...
5 days ago · The Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis (AVATAR) trial is an investigator-initiated, prospective, multinational, randomized, controlled, parallel-group, event-driven trial that compared the safety and efficacy of early surgery in the treatment of truly asymptomatic patients with severe AS and LV ejection fraction (LVEF) ≥ 50% vs. conservative treatment with watchful waiting strategy and AVR only after symptom onset, or other ...
Apr 8, 2024 · Methods. In this randomized noninferiority trial conducted at 38 sites in Germany, we assigned patients with severe aortic stenosis who were at low or intermediate surgical risk to undergo either ...
Sep 1, 2024 · Here, the results of extended follow-up of the AVATAR trial are reported (NCT02436655, clinical trials.gov). Methods: The AVATAR trial randomly assigned patients with severe, asymptomatic AS and LV ejection fraction ≥50% to undergo either early surgical aortic valve replacement (AVR) or conservative treatment with watchful waiting strategy.
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