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May 3, 2023 · ADALAT XL (nifedipine extended-release tablets) is a calcium ion influx inhibitor (calcium channel blocker or calcium ion antagonist). ADALAT XL, while similar in appearance to a conventional tablet, nonetheless consists of a semipermeable membrane surrounding an osmotically active drug core.
Mar 26, 1992 · ADALAT XL (nifedipine extended-release tablets) is indicated in the management of chronic stable angina (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta blockers and/or nitrates, or who cannot tolerate these agents.
Sep 19, 2023 · Adalat XL has direct negative inotropic effects on cardiac muscles and these effects are seen at higher doses than dose which causes arterial vasodilatation. Adalat XL is an inhibitor of L-type voltage gated calcium channels that reduces blood pressure and increases oxygen supply to the heart.
- Prescription only
- Adalat XL
- Nifedipine
Adalat ® CC is an extended release tablet dosage form of the calcium channel blocker nifedipine. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4- (2-nitrophenyl)-dimethyl ester, C 17 H 18 N 2 O 6, and has the structural formula:
- Uses For Nifedipine
- Nifedipine Dosage and Administration
- Cautions For Nifedipine
- Drug Interactions
- Actions
- Advice to Patients
- Additional Information
- Preparations
Angina
Management of Prinzmetal variant angina and chronic stable angina. A drug of choice for the management of Prinzmetal variant angina (used alone or in combination with nitrates). β-Blockers are recommended as the anti-ischemic drugs of choice in most patients with chronic stable angina; calcium-channel blockers may be substituted or added in patients who do not tolerate or respond adequately to β-blockers. Also has been used in patients with unstable angina† [off-label]; however, nondihydropyr...
Hypertension
Management of hypertension, alone or in combination with other classes of antihypertensive agents. Only extended-release formulations currently are recommended for management of hypertension. (See Cautions.) Calcium-channel blockers are recommended as one of several preferred agents for the initial management of hypertension according to current evidence-based hypertension guidelines; other preferred options include ACE inhibitors, angiotensin II receptor antagonists, and thiazide diuretics....
Raynaud’s Phenomenon
Drug of choice for the management of Raynaud’s phenomenon† [off-label], preferably administered as extended-release formulations.
Dosage
Manufacturer states that two 30-mg Adalat CC extended-release tablets may be interchanged with one 60-mg Adalat CC extended-release tablet; however, three 30-mg Adalat CC extended-release tablets should not be considered interchangeable with one 90-mg AdalatCC extended-release tablet.
Contraindications
1. Known hypersensitivity to nifedipine or any ingredient in the formulation.
Common Adverse Effects
Dizziness, lightheadedness, giddiness, flushing, heat sensation, headache, tremor, nervousness, mood changes, weakness, fatigue, asthenia, muscle cramps, nausea, heartburn, peripheral edema, dyspnea, cough, wheezing, nasal congestion, sore throat.
Metabolized by CYP isoenzymes, principally CYP3A.May inhibit CYP3A; does not appear to affect CYP2D6.
Inhibits transmembrane influx of extracellular calcium ions across the membranes of myocardial cells and vascular smooth muscle cells, without changing serum calcium concentrations.Peripheral arterial vasodilator; acts directly on vascular smooth muscle causing reduction in peripheral vascular resistance (afterload) and BP.Importance of swallowing extended-release tablets whole; do notchew, crush, or break.Importance of advising patients receiving extended-release tablets that tablet core may be excreted in stools without affecting drug efficacy.Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.The American Society of Health-System Pharmacists, Inc. represents that the information provided in the accompanying monograph was formulated with a reasonable standard of care, and in conformity with professional standards in the field. Readers are advised that decisions regarding use of drugs are complex medical decisions requiring the independen...
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Centerfor information on shortages of one or more of these preparations. * available from one or more manufacturer, distributor, and/or repa...
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Adalat XL: Nifedipine belongs to the class of medications called calcium channel blockers. It is used to treat high blood pressure and angina (chest pain brought on by exercise or stress). It works to control blood pressure and reduce the number of angina attacks by relaxing blood vessels.
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ADALAT® XL® Bayer Nifedipine Antianginal – Antihypertensive System Components and Performance: Adalat XL extended release tablets, while similar in appearance to a conventional tablet, nonetheless consist of a semipermeable membrane surrounding an osmotically active drug core. The core itself is divided into 2 layers: an “active” layer ...
