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Sep 25, 2023 · Adalat CC is an extended release dosage form and tablets should be swallowed whole, not bitten or divided. In general, titration should proceed over a 7-14 day period starting with 30 mg once daily. Upward titration should be based on therapeutic efficacy and safety.
- Side Effects
Adalat CC Side Effects. Generic name: nifedipine Medically...
- Drug Interactions
Adalat CC Interactions. There are 610 drugs known to...
- Adalat Cc 30 Pill
ADALAT CC 30 Pill - pink round, 15mm . Generic Name:...
- Adalat Cc Advanced Reading
Precautions while using Adalat CC. It is very important that...
- Side Effects
- CYP3A Inhibitors
- Strong CYP3A Inducers
- Cardiovascular Drugs
- Calcium Channel Blockers
- Ace Inhibitors
- Angiotensin-Ii Blockers
- Beta-Blockers
- Central alpha1-blockers
- Digitalis
- Antithrombotics
CYP3A inhibitors such as ketoconazole, fluconazole,itraconazole, clarithromycin, erythromycin (Azithromycin, although structurallyrelated to the class of macrolide antibiotic is voidof clinically relevantCYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir,nelfinavir, and ritonavir may result in increased exposure to nifedi...
Strong CYP3A inducers, such as rifampin, rifabutin,phenobarbital, phenytoin, carbamazepine, and St. John's Wort reduce thebioavailability and efficacy of nifedipine; therefore nifedipine should not be usedin combination with strong CYP3A inducers such as rifampin (SeeCONTRAINDICATIONS).
Quinidine: Quinidine is a substrate of CYP3A andhas been shown to inhibit CYP3A in vitro. Coadministration of multiple doses ofquinidine sulfate, 200 mg t.i.d., and nifedipine, 20 mg t.i.d., increased Cmaxand AUC of nifedipine in healthy volunteers by factors of 2.30 and 1.37,respectively. The heart rate in the initial interval after drug administr...
Diltiazem: Pre-treatment of healthy volunteerswith 30 mg or 90 mg t.i.d. diltiazem p.o. increased the AUC of nifedipine aftera single dose of 20 mg nifedipine by factors of 2.2 and 3.1, respectively. The correspondingCmax values of nifedipine increased by factors of 2.0 and 1.7, respectively.Caution should be exercised when co-administering diltiaz...
Benazepril: In healthy volunteers receiving singledose of 20 mg nifedipine ER and benazepril 10 mg, the plasma concentrations ofbenazeprilat and nifedipine in the presence and absence of each other were notstatistically significantly different. A hypotensive effect was only seen afterco-administration of the two drugs. The tachycardic effect of nif...
Irbesartan: In vitrostudies show significantinhibition of the formation of oxidized irbesartan metabolites by nifedipine.However, in clinical studies, concomitant nifedipine had no effect on irbesartanpharmacokinetics. Candesartan:No significant drug interaction hasbeen reported in studies with candesartan cilexitil given together withnifedipine. B...
Adalat CC was well tolerated when administered incombination with beta-blockers in 187 hypertensive patients in aplacebo-controlled clinical trial. However, there have been occasionalliterature reports suggesting that the combination nifedipine andbeta-adrenergic blocking drugs may increase the likelihood of congestive heartfailure, severe hypotens...
Doxazosin: Healthy volunteers participating in amultiple dose doxazosin-nifedipine interaction study received 2 mg doxazosinq.d. alone or combined with 20 mg nifedipine ER b.i.d. Co-administration of nifedipineresulted in a decrease in AUC and Cmax of doxazosin to 83% and 86% of thevalues in the absence of nifedipine, respectively. In the presence ...
Digoxin:The simultaneous administration ofnifedipine and digoxin may lead to reduced clearance resulting in an increasein plasma concentrations of digoxin. Since there have been isolated reports of patientswith elevated digoxin levels, and there is a possible interaction betweendigoxin and Adalat CC, it is recommended that digoxin levels be monitor...
Coumarins: There have been rare reports ofincreased prothrombin timein patients taking coumarin anticoagulants to whomnifedipine was administered. However the relationship to nifedipine therapy is uncertain.
Apr 8, 2024 · Adalat CC belongs to a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels. Adalat CC is used to treat hypertension (high blood pressure) or angina (chest pain). Adalat CC may also be used for purposes not listed in this medication guide.
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- You should not use Adalat CC if you are allergic to nifedipine, if you have severe coronary artery disease, or if you have had a heart attack withi...
- Take Adalat CC exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dos...
- Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
- Other drugs may interact with nifedipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your h...
Aug 24, 2010 · Adalat CC tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration. Inert ingredients in the formulation are: hydroxypropylcellulose, lactose, corn...
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Instructions. Adalat CC is to be taken by mouth on an empty stomach. The usual dose is once daily or as instructed by your doctor. Swallow the tablets whole. Do not crush or chew this medication because it will release all particles of the drug at once, thus increasing the risk for side effects. Do not split tablets without a score line.
What is the dosage for nifedipine? Which drugs or supplements interact with nifedipine? Is nifedipine safe to use during pregnancy or while breastfeeding? What else should I know about nifedipine? What is nifedipine?
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What is Nifedipine? Nifedipine oral tablet is a prescription drug that is available as Adalat CC, Afeditab CR, and Procardia XL brand-name products. These are tablets with extended-release. Over time, an extended-release drug is released into the bloodstream slowly.
