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The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base. The reaction produces a β-keto ester or a β- diketone . [1]
The Claisen condensation reaction is an organic coupling reaction that results in the formation of a C-C bond between either a single ester and one carbonyl compound or between two esters. The reaction proceeds when a strong base is present and the product of the reaction is a beta-keto ester or a beta-diketone.
Jan 15, 2023 · write an equation to illustrate a Claisen condensation reaction. write a detailed mechanism for a Claisen condensation reaction or its reverse. identify the product formed in a given Claisen condensation reaction.
Sep 14, 2020 · In the Claisen condensation, an ester (2 equivalents) is treated with a base (1 equivalent); the product is a called “beta-keto” ester, since a ketone is located two carbons away (beta) from the ester carbonyl. It forms a new C-C bond and breaks a C-O and C-H bond. The Dieckmann condensation is the name given to an intramolecular Claisen ...
The Claisen Condensation between esters containing α-hydrogens, promoted by a base such as sodium ethoxide, affords β-ketoesters. The driving force is the formation of the stabilized anion of the β-keto ester.
Jan 23, 2023 · Claisen Condensation. Page ID. Organic Reactions Wiki. The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base, resulting in a β-keto ester or a β-diketone.
The Claisen condensation of an ester results in loss of one molecule of alcohol and formation of a product in which an acyl group of one reactant bonds to the α carbon of the second reactant. The product is a β -keto ester.
The Claisen condensation of an ester results in loss of one molecule of alcohol and formation of a product in which an acyl group of one reactant bonds to the α carbon of the second reactant. The product is a β -keto ester. Solution. (CH 3) 2 CHCH 2 CO 2 Et. (b) Ethyl phenylacetate (c) Ethyl cyclohexylacetate.
The Claisen condensation – strictly the condensation of two esters with the concomitant release of one of the constituent alcohol moieties – is arguably the most important carbon–carbon bond-forming reaction in biology, as it is used in the biosynthesis of fatty acids, polyketides, and a large variety of other essential small molecule ...
In this article, we learn about the Claisen Condensation, an important organic reaction, including its mechanism, its important variants, and its use in biology.
