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The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence . The Hayflick limit has been found to correlate with the length of the telomeric region at the end of chromosomes.
Telomere shortening limits the lifespan of primary human cells to a finite number of cell divisions, which is 50–70 for human fibroblast. This limit is called after the discoverer – the ‘ Hayflick limit ’ (Hayflick, 1965).
Oct 1, 2000 · Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick ...
Nov 14, 2014 · The concept of the Hayflick Limit helped scientists study the effects of cellular aging on human populations from embryonic development to death, including the discovery of the effects of shortening repetitive sequences of DNA, called telomeres, on the ends of chromosomes.
Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent -- a phenomenon now known as the 'Hayflick limit'.
Hayflick limit or Hayflick’s phenomena is defined as the number of times a normal cell population divides before entering the senescence phase. Macfarlane Burnet coined the term “c limit” in 1974.
Jun 18, 2011 · Now 83 years old, Hayflick no longer has his own laboratory, but is still closely involved with ageing. He writes, lectures, does consultancy work, and, in a satisfying manifestation of natural justice, reckons that the ageing process is treating him well.
