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The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence . The Hayflick limit has been found to correlate with the length of the telomeric region at the end of chromosomes.
Hayflick limit is the number of times a cell can divide before reaching senescence or crisis. Learn how telomeres, telomerase, and chaperones are involved in the regulation of cellular aging and replicative capacity.
Oct 1, 2000 · Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick ...
- Jerry W. Shay, Woodring E. Wright
- 2000
Nov 14, 2014 · The Hayflick Limit is a concept that explains the mechanisms behind cellular aging. It states that a normal human cell can only replicate and divide forty to sixty times before it dies by apoptosis. Learn about the history, research and applications of this theory.
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Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent -- a phenomenon now known as the 'Hayflick limit'.
- Jerry W. Shay, Woodring E. Wright
- 2000
Learn about the Hayflick limit, the number of times a normal cell population divides before entering senescence, and its relation to telomere length, aging, and cancer. Explore chapters and articles from various books and journals on this topic.
Jun 18, 2011 · Now 83 years old, Hayflick no longer has his own laboratory, but is still closely involved with ageing. He writes, lectures, does consultancy work, and, in a satisfying manifestation of natural justice, reckons that the ageing process is treating him well.
