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Aug 25, 2023 · In this study, we propose a deep generative model that combines a stochastic differential equation (SDE)-based diffusion model with a pretrained autoencoder. The molecular generator enables efficient generation of molecules that target multiple opioid receptors, including mu, kappa, and delta.
Jun 13, 2023 · Multi-objective Molecular Optimization for Opioid Use Disorder Treatment Using Generative Network Complex. Hongsong Feng, Rui Wang, Chang-Guo Zhan, Guo-Wei Wei. Opioid Use Disorder (OUD) has emerged as a significant global public health issue, with complex multifaceted conditions.
Abstract. Opioid Use Disorder (OUD) has emerged as a significant global public health issue, with complex multifaceted conditions. Due to the lack of effective treatment options for various conditions, there is a pressing need for the discovery of new medications.
Jun 13, 2023 · Multi-objective Molecular Optimization for Opioid Use Disorder Treatment Using Generative Network Complex | Papers With Code. 13 Jun 2023 · Hongsong Feng , Rui Wang , Chang-Guo Zhan , Guo-Wei Wei ·. Edit social preview. Opioid Use Disorder (OUD) has emerged as a significant global public health issue, with complex multifaceted conditions.
Changhong SONG | Cited by 822 | of U.S. Food and Drug Administration, Maryland (FDA) | Read 25 publications | Contact Changhong SONG.
Aug 25, 2023 · Hongsong Feng Guo-Wei Wei Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to...
A deep generative model that combines a stochastic differential equation (SDE)-based diffusion modeling with the latent space of a pretrained autoencoder model enables efficient generation of molecules that are effective on multiple targets, specifically the mu, kappa, and delta opioid receptors.
