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In the late 1950s and early 1960s, the use of thalidomide in 46 countries by women who were pregnant or who subsequently became pregnant resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands of miscarriages.
Thalidomide is a known human teratogen and carries an extremely high risk of severe, life-threatening birth defects if administered during pregnancy. It causes skeletal deformities such as amelia (absence of legs and/or arms), absence of bones, and phocomelia (malformation of the limbs).
Apr 19, 2011 · The thalidomide tragedy marked a turning point in toxicity testing, as it prompted United States and international regulatory agencies to develop systematic toxicity testing protocols; the use of thalidomide as a tool in developmental biology led to important discoveries in the biochemical pathways of limb development.
Mar 23, 2020 · Overseas, thousands of babies in Germany, England and other countries were being born with severe defects tied to their mothers’ use of thalidomide, a drug widely taken for insomnia, morning ...
Jun 4, 2015 · Abstract. Nearly 60 years ago thalidomide was prescribed to treat morning sickness in pregnant women. What followed was the biggest man‐made medical disaster ever, where over 10,000 children were born with a range of severe and debilitating malformations.
Nov 3, 2011 · After a German newspaper reported that Thalidomide was the likely cause for the mysterious spate of disabled babies born in Germany since 1958, the drug's producer, Chemie Gruenenthal, caved in...
Dec 11, 2019 · Introduction. Thalidomide in the marketplace. Thalidomide and pregnancy. The thalidomide scandal. The consequences of thalidomide. Uses of thalidomide today. Living with thalidomide impairments. Find out more. Thalidomide changed our relationship with new medicines for ever.
Nov 2, 2021 · 1. Overview. Thalidomide is used around the world today to effectively treat inflammatory and cancer conditions. Yet, 60 years ago, it was withdrawn from the market. What do we know about its mechanisms of action and how safe it is? 2. History and withdrawal.
Aug 1, 2018 · More than 60 years after the drug thalidomide caused birth defects in thousands of children whose mothers took the drug while pregnant, scientists at Dana-Farber Cancer Institute have solved a mystery that has lingered ever since the dangers of the drug first became apparent: how did the drug produce such severe fetal harm?
Jul 5, 2023 · In the 1960s, FDA inspector Frances Kelsey was assigned her first drug to review: thalidomide. Her thorough investigation led her to discover that the drug had caused pregnant women to bear...
