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The goal of a Zika virus vaccine is to produce specific antibodies against the Zika virus to prevent infection and severe disease. The challenges in developing a safe and effective vaccine include limiting side effects such as Guillain-Barré syndrome , a potential consequence of Zika virus infection.
Dec 8, 2022 · No vaccine is yet available for the prevention or treatment of Zika virus infection. Development of a Zika vaccine remains an active area of research. Mosquito bites
May 31, 2020 · These include: nucleic acid vaccines (DNA and RNA vaccines), inactivated whole virus vaccines, live attenuated vaccines, viral vectored vaccines, protein antigen vaccines in the form of purified proteins from expression systems, or virus-like particles.
NIAID is developing multiple vaccine candidates to prevent Zika virus infection. These include: A DNA-based vaccine developed by scientists at NIAID’s Vaccine Research Center (VRC). The strategy is similar to the VRC’s investigational flavivirus vaccine for West Nile virus infection.
Oct 28, 2022 · These vaccines have been shown to induce specific humoral and cellular immune responses and reduce viremia and viral RNA titers, both in vitro and in vivo. This review provides a comprehensive summary of current advancements in the development of vaccines against Zika virus.
Nov 30, 2020 · The emergence and rapid spread of Zika virus (ZIKV) on a global scale as well as the establishment of a causal link between Zika infection and congenital syndrome and neurological disorders triggered unprecedented efforts towards the development of a safe and effective Zika vaccine.
In this review, we survey current vaccine efforts, preclinical and clinical results, and ethical and other concerns that directly bear on vaccine development. It is clear that the world needs safe and effective vaccines to protect against Zika virus infection.
Jan 19, 2023 · Developing a safe and immunogenic vaccine against Zika virus remains an unmet medical need. We did two phase 1 studies that evaluated the safety and immunogenicity of two mRNA-based Zika virus vaccines (mRNA-1325 and mRNA-1893) in adults.
23 July 2018. The 2015–2016 outbreak of Zika virus disease in the Region of the Americas demonstrated how a relatively obscure and mild mosquito-borne disease can become a global health emergency, causing congenital Zika syndrome, including microcephaly, and neurological complications such as Guillain-Barré syndrome.
Aug 3, 2016 · That vaccine candidate was found to be safe and induced an immune response when tested in a Phase 1 clinical trial. The investigational Zika vaccine includes a small, circular piece of DNA — called a plasmid — that scientists engineered to contain genes that code for proteins of the Zika virus.
