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What is drug deterioration?
How does physical degradation affect pharmacological properties?
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What causes drug degradation?
Mar 25, 2021 · In this science article, Timothy J. Snape, Alison M. Astles and Janice Davies discuss the chemical basis for the stability of certain functional groups within drug molecules against hydrolytic degradation and consider the methods used to maximise their stability on storage.
Jul 27, 2023 · Drug deterioration is when a drug loses some of its strength, effectiveness, or safety due to chemical or physical changes that happen over time. Degradation can happen because of things like temperature, humidity, exposure to light, oxygen, pH, and reactions with the packing.
Degradation studies are an important aspect of preformulation evaluation of the stability of drug candidates. These experiments aim to aid further formulation development by evaluating the intrinsic stability properties of a drug candidate in a timely manner by deliberately applying stress to cause degradation.
Nov 2, 2020 · Mostly deterioration of dosage forms results in the destruction of the physical appearance and efficacy of the product. Other possible complications include sorption, evaporation, and contamination of drugs.
- Tauqeer Hussain Mallhi, Rabia Khokhar, Aisha Khokhar, Syed Nasir Abbas Bukhari, Yusra Habib Khan
- 2020
Deterioration. It is important to be familiar with the normal aspects of each drug (colour, odour, solubility, consistency) in order to detect changes, which may indicate its deterioration. It is important to know that deterioration does not always lead to a detectable external modification.
Jan 29, 2022 · Oxidation is the second most common degradation pathway for pharmaceuticals, after hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex and produces a wider range of degradation products; oxidation is thus harder to control.
Oct 28, 2022 · Stability is defined as the quality of being stable, and applying this wide concept into pharmaceutical formulations is considered as the absence of changes in characteristics and properties of the product at the time of its manufacture [3].
