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  2. With the aim to ensure that all of the inhaled CO would also bind to hemoglobin and become distributed equally throughout the circulation, Haldane and Smith performed the measurements using an impressive 2 hours of re-breathing.

  3. Nov 12, 2018 · Application of CO Rebreathing. oCORM was applied in all subjects and determines Hbmass through labeling hemoglobin (Hb) with inhaled CO, resulting in a temporarily increased COHb.

    • Christoph Ahlgrim, Philipp Birkner, Florian Seiler, Sebastian Grundmann, Manfred W. Baumstark, Chris...
    • 10.3389/fphys.2018.01603
    • 2018
    • Front Physiol. 2018; 9: 1603.
  4. Mar 24, 2020 · Anemia is common in liver cirrhosis. This generally infers a fall in total hemoglobin mass (tHb‐mass). However, hemoglobin concentration ([Hb]) may fall due to an expansion in plasma volume (PV). The “optimized carbon monoxide rebreathing method” (oCOR) measures tHb‐mass directly and PV (indirectly using hematocrit).

    • James O.M. Plumb, James M. Otto, Shriya B. Kumar, Mark Wright, Walter Schmidt, Michael P.W. Grocott,...
    • 10.14814/phy2.14402
    • 2020
    • Physiol Rep. 2020 Mar; 8(6): e14402.
  5. In 2005, Schmidt and Prommer introduced an “optimized CO rebreathing method” with only 2 min of rebreathing and inhalation of the whole CO bolus within the first several seconds. The “optimized CO rebreathing method” requires patient cooperation for specific breathing maneuvers.

    • Roberto Falz, Martin Busse
    • 10.14814/phy2.13849
    • 2018
    • Physiol Rep. 2018 Sep; 6(17): e13849.
  6. Mar 6, 2024 · CO binds to hemoglobin with much greater affinity than oxygen, forming carboxyhemoglobin (COHb) and resulting in impaired oxygen transport and utilization. CO can also precipitate an inflammatory cascade that results in central nervous system (CNS) lipid peroxidation and delayed neurologic sequelae.

  7. Jun 4, 2024 · The optimized carbon monoxide (CO) rebreathing method is used in exercise physiology to measure hemoglobin parameters. Read the article to learn more about it.