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Muscle is a bioinformatics tool for aligning and comparing protein or nucleotide sequences. It offers better accuracy and speed than other methods, depending on the options chosen.
MUSCLE is widely-used software for making multiple alignments of biological sequences. Version 5 of MUSCLE achieves highest scores on Balibase, Bralibase and Balifam benchmark tests and scales to thousands of sequences on a commodity desktop computer.
Aug 19, 2004 · Multiple Sequence Alignment Program. In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUSCLE to achieve the highest scores reported to date on four alignment accuracy benchmarks.
- Robert C Edgar
- bob@drive5.com
- 2004
MUltiple Sequence Comparison by Log-Expectation ( MUSCLE) is computer software for multiple sequence alignment of protein and nucleotide sequences. It is licensed as public domain. The method was published by Robert C. Edgar in two papers in 2004.
Mar 19, 2004 · The speed and accuracy of MUSCLE are compared with T-Coffee, MAFFT and CLUSTALW on four test sets of reference alignments: BAliBASE, SABmark, SMART and a new benchmark, PREFAB. MUSCLE achieves the highest, or joint highest, rank in accuracy on each of these sets.
muscle. Multiple Sequence Alignment with MUSCLE. DOI: 10.18129/B9.bioc.muscle. Bioconductor version: Release (3.19) MUSCLE performs multiple sequence alignments of nucleotide or amino acid sequences. Author: Algorithm by Robert C. Edgar. R port by Alex T. Kalinka. Maintainer: Alex T. Kalinka <alex.t.kalinka at gmail.com>
With options designed for high-throughput applications, MUSCLE gives average accuracy statistically indistinguishable from T-Coffee and is the fastest published method for large numbers of sequences, able to align 5,000 sequences of length 300 in 7 minutes on a desktop computer. MUSCLE is freely available at http://www.drive5.com/muscle.
