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Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts.
Jun 20, 2023 · Three different types of excision repair have been characterized: nucleotide excision repair, base excision repair, and mismatch repair. All utilize a cut, copy, and paste mechanism. In the cutting stage, an enzyme or complex removes a damaged base or a string of nucleotides from the DNA.
May 25, 2022 · Nucleotide excision repair (NER) is a major pathway to deal with bulky adducts induced by various environmental toxins in all cellular organisms. The two sub-pathways of NER, global genome repair (GGR) and transcription-coupled repair (TCR), differ in the damage recognition modes.
Jun 23, 2014 · Nucleotide excision repair (NER) eliminates structurally diverse DNA lesions by repairing helix-distorting damage throughout the genome as well as transcription-blocking lesions.
Nucleotide excision repair (NER) is the main pathway responsible for the removal of bulky DNA lesions induced by UV irradiation, environmental mutagens, and certain chemotherapeutic agents.
At least five major DNA repair pathways—base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR) and non-homologous end joining (NHEJ)—are active throughout different stages of the cell cycle, allowing the cells to repair the DNA damage.
Jul 9, 2021 · Nucleotide excision repair refers to repair of DNA replication lesions or bulky adducts arising from distortions of the DNA structure. 3,200 Mismatch repair refers to adjustment of mismatched...
Jan 1, 2018 · The nucleotide excision repair (NER) pathway is a highly efficient and versatile mechanism for the repair of bulky DNA lesions. The majority of such lesions arise exogenously, such as those inflicted by UV light exposure or DNA-alkylating carcinogens.
Excision repair involves removal of a damaged nucleotide by dual incisions bracketing the lesion; this is accomplished by a multisubunit enzyme referred to as the excision nuclease or excinuclease.
In nucleotide excision repair, the damaged nucleotide(s) are removed along with a surrounding patch of DNA. In this process, a helicase (DNA-opening enzyme) cranks open the DNA to form a bubble, and DNA-cutting enzymes chop out the damaged part of the bubble.
