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Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and for many other biological effects. In humans, the most important compounds in this group are vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol).
Dec 31, 2021 · Various foods such as cod liver oil and irradiation of other foods including plants were found to prevent or cure this disease, leading eventually to the discovery of the active principle—vitamin D. Vitamin D comes in two forms (D 2 and D 3) which differ chemically in their side chains.
- Daniel Bikle
- 2021/12/31
- 2014
Mar 3, 2014 · Vitamin D 3 is made in the skin from 7-dehydrocholesterol under the influence of UV light. Vitamin D 2 (ergocalciferol) is derived from the plant sterol ergosterol. Vitamin D is metabolized first to 25 hydroxyvitamin D (25OHD), then to the hormonal form 1,25-dihydroxyvitamin D (1,25 (OH) 2 D).
- Daniel D. Bikle
- 10.1016/j.chembiol.2013.12.016
- 2014
- 2014/03/03
Apr 20, 2021 · Results from clinical studies investigating the dose–response curve to vitamin D are markedly variable, attributable to various dosing regimen, administrative routes, assay methods for measuring 25(OH)D, demographics, and also regulation of endogenous vitamin D production, which, as mentioned above, also depends on several factors.
- Ligia J. Dominguez, Mario Farruggia, Nicola Veronese, Mario Barbagallo
- 2021
Feb 6, 2020 · Vitamin D is produced in the skin. It is subsequently metabolized to its hormonally active form, 1,25-dihydroxyvitamin D (1,25 (OH) 2 D), by the 1-hydroxylase and catabolized by the...
- Daniel Bikle, Daniel Bikle, Sylvia Christakos
- 2020
Vitamin D is essential for regulating numerous biologic processes through the widespread distribution of its receptor and activating enzymes. This review by Bikle examines vitamin D production and metabolism, its mechanisms of actions, and the clinical utility of its metabolites and analogs.
Vitamin D production in the skin is the primary natural source of vitamin D, but many people have insufficient levels because they live in places where sunlight is limited in winter, or because they have limited sun exposure due to being inside much of the time.
