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  1. Mar 1, 2002 · In this paper, we extend to human mast cells and human KIT our original observations on different classes of activating KIT mutations and their tendency to be inhibited by different pharmacologic agents.

    • Yongsheng Ma, Shan Zeng, Dean D. Metcalfe, Cem Akin, Sasa Dimitrijevic, Joseph H. Butterfield, Geral...
    • 2002
  2. Jul 1, 2012 · Definition / general. Most cutaneous mast cell disorders have a good prognosis. Mastocytosis: monomorphic population of mast cells with rare eosinophils. Telangiectasia macularis eruptive perstans (TMEP): telangiectatic light or dark brown macules.

  3. Jul 17, 2022 · Systemic mastocytosis (SM) is a highly heterogeneous disease characterized by clonal (usually KIT mutants) proliferation and accumulation of abnormal mast cells in one or more extracutaneous organs, for example, the bone marrow, gastrointestinal tract, or liver, with a plethora of distinct presentations ranging from high mast cell burden to orga...

    • 10.3390/cancers14143474
    • 2022/07
    • Cancers (Basel). 2022 Jul; 14(14): 3474.
  4. Jun 20, 2023 · Specific qualitative and quantitative findings are lacking for inflammatory mast cellmediated disorders. This review covers histopathologic features of mast cell disorders that affect the gastrointestinal tract and offers practical guidance for their assessment in mucosal biopsies.

  5. Dec 12, 2019 · Mast cells (MCs) are portions of the innate and adaptive immune system derived from bone marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype, and function are determined by their microenvironment. MCs accumulate at inflammatory sites associated with atopy, wound healing, and malignancies.

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  7. Mar 19, 2020 · Mast cells are innate immune cells that intersect with the adaptive immunity and play a crucial role in the initiation of allergic reactions and the host defense against certain parasites and venoms.