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  2. 4 days ago · Immune system - Macrophages, Antigens, Defense: The other main type of scavenger cell is the macrophage, the mature form of the monocyte. Like granulocytes, monocytes are produced by stem cells in the bone marrow and circulate through the blood, though in lesser numbers.

  3. 11 hours ago · M2 macrophages are stimulated by cytokines such as IL-4, IL-10, and IL-13; glucocorticoids and immunoglobulin complexes or Toll-like Receptor (TLR) ligands [35]. M2 macrophages are part of the Th2 immune response, which promotes anti-inflammatory responses and helps in wound healing, inflammatory regression, and tumour progression [39]. The ...

  4. 1 day ago · With “OrgaPlexing” Max Planck researchers reveal how immune cells organize their intracellular architecture to control inflammatory processes. July 05, 2024. Scientists at the Max Planck Institute of Immunobiology and Epigenetics have developed a novel imaging method that illuminates how macrophages, key sentinel cells of the immune system ...

  5. 3 days ago · Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located along the brain vasculature at the interface ...

  6. 1 day ago · Repolarizing tumor-associated macrophages (TAMs) into tumor-inhibiting M1 macrophages has been considered a promising strategy for enhanced cancer immunotherapy. However, several immunosuppressive ligands (e.g., LSECtin) can still be highly expressed on M1 macrophages, inducing unsatisfactory therapeutic outcomes. We herein developed an antibody-decorated nanoplatform composed of PEGylated iron oxide nanoparticles (IONPs) and LSECtin antibody conjugated onto the surface of IONPs via the ...

  7. 2 days ago · TNF-α-producing macrophages and MSCs positively correlate and interact with each other in the bone healing process of the extracted tooth socket. RNA sequencing of TNF-α-induced MSCs revealed 15 genes that are candidates to induce MSC function during bone repair. Among them, Mmp3, Gbp6, Cxcl10, Clec4e, Ccl20, and Nos2 may regulate MSC ...

  8. 3 days ago · Macrophages produce high levels of GDF-15 during oxidative and lysosomal stress, which can lead to fibrogenesis and angiogenesis at the tissue level. At the same time, macrophages can respond to ...

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