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  1. 5 days ago · Approximately 8% of patients with a prostate biopsy result of Gleason grade group (GGG) 1 have occult high-risk prostate cancer. Maintaining the “cancer” classification for GGG 1 for cases with >50% positive systematic biopsy cores or prostate-specific antigen >20 ng/ml may minimize the risk of mortality for these patients.

  2. 2 days ago · Garzotto and coworkers reported that PSA doubling time is an independent risk factor for detection of aggressive prostate cancer (defined as Gleason > 7) after an initial negative prostate biopsy. Therefore, PSA doubling time may be helpful in reducing unnecessary biopsies and overtreatment of prostate cancer.

  3. 3 days ago · Purpose To develop a radiomics-based model using [68Ga]Ga-PSMA PET/CT to predict postoperative adverse pathology (AP) in patients with biopsy Gleason Grade Group (GGG) 1–2 prostate cancer (PCa), assisting in the selection of patients for active surveillance (AS). Methods A total of 75 men with biopsy GGG 1–2 PCa who underwent radical prostatectomy (RP) were enrolled. The patients were randomly divided into a training group (70%) and a testing group (30%). Radiomics features of entire ...

  4. 2 days ago · Consistent with our results, EAF2 gene expression was reduced in the high Gleason score group compared to the low Gleason score group (Fig. 1D), and EAF2 expression was negatively correlated with Progress Free Interval (PFI) (Fig. 1E). These results suggest that downregulation of EAF2 expression, as a tumor suppressor, is associated with a higher tumor grade and poorer prognosis in prostate cancer.

  5. 2 days ago · This paper presents a novel approach to enhance the accuracy of patch-level Gleason grading in prostate histopathology images, a critical task in the diagnosis and prognosis of prostate cancer. This study shows that the Gleason grading accuracy can be improved by addressing the prevalent issue of label inconsistencies in the SICAPv2 prostate dataset, which employs a majority voting scheme for patch-level labels. We propose a multi-label ensemble deep-learning classifier that effectively ...

  6. 4 days ago · The Gleason score is an important predictor of prognosis in prostate cancer. However, its subjective nature can result in over- or under-grading. Our objective was to train an artificial intelligence (AI)-based algorithm to grade prostate cancer in specimens from patients who underwent radical ...

  7. 4 days ago · Emphysematous pyelonephritis (plural: emphysematous pyelonephritides) refers to a morbid infection with particular gas formation within or around the kidneys. If not treated early, it may lead to fulminant sepsis and, therefore, carries a high mortality. Clinical presentation. The patient usually presents with fevers and flank pain.

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