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Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
Fibronectin is an extracellular glycoprotein that helps organize and maintain homeostasis of the extracellular matrix [93]. Fibronectin binds to collagen, functions in cell adhesion, migration, and differentiation, and regulates cell-matrix and matrix-matrix interactions [94].
Fibronectin, an abundant and ubiquitous protein of the extracellular matrix, forms a fibrillar network by interacting directly with cell surface receptors [2 ]. It is synthesized by a variety of different cells and is secreted as a disulfide-bonded dimer with 230–270 kDa subunits ( Figure 43.1 ).
Jun 15, 2021 · Human plasma fibronectin is an adhesive protein that plays a crucial role in wound healing. Many studies had indicated that glycans might mediate the expression and functions of fibronectin, yet a comprehensive understanding of its glycosylation is still missing.
Feb 1, 2018 · Our goal was to evaluate the performance of fetal fibronectin (fFN) test alone or combined with cervical length (CL), to predict spontaneous preterm birth (PTB) in symptomatic twin pregnancies.
Fetal fibronectin is a glycoprotein that leaks into cervical and vaginal secretions owing to mechanical factors such as uterine contractions or inflammatory products ascending in the cervical canal. A negative fetal fibronectin test result from anywhere between 22 and 35 weeks is highly predictive of labour not occurring and has been used to ...
The cost effectiveness of fetal fibronectin (fFN) testing in suspected premature labour.
