Search results
3 days ago · 5.3 Malaria parasites. Malaria is caused by Plasmodium parasites. Plasmodium parasites infect people and attack the red blood cells, which often leads to severe illness and death. The parasites are spread to people through the bites of infected Anopheles mosquitoes, which are the malaria vectors and which bite mainly between dusk and dawn.
3 days ago · Background The World Health Organization 2022 malaria chemoprevention guidelines recommend providing a full course of antimalarial treatment at pre-defined intervals, regardless of malaria status to prevent illness among children resident in moderate to high perennial malaria transmission settings as perennial malaria chemoprevention (PMC) with sulfadoxine-pyrimethamine (SP). The dhps I431V mutation circulating in West Africa has unknown effect on SP protective efficacy. Methods This ...
3 days ago · Researchers have developed MED6-189, a new drug effective against drug-sensitive and drug-resistant strains of human malaria parasites. MED6-189 targets the apicoplast and vesicular trafficking pathways in Plasmodium falciparum, blocking parasite development and preventing drug resistance. This synthetic compound, inspired by marine sponges ...
3 days ago · In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite.For decades, the parasite's resistance to ...
5 days ago · This article examines the historical and ongoing efforts to fight malaria, a parasitic disease caused by Plasmodium species and transmitted by Anopheles mosquitoes. Despite over a century of control efforts, malaria remains a major global health issue. In 2022, there were an estimated 249 million cases across 85 countries, leading to approximately 600,000 deaths. In the recently published Global Technical Strategy for Malaria 2016–2030, the World Health Organization (WHO) has prioritized ...
3 days ago · We show that MED6-189, one of our most accessible synthetic analogs of kalihinols A and B, inhibits drug-sensitive and drug-resistant P. falciparum strains in vitro, blocks parasite sexual differentiation, and eliminates infection in a humanized mouse model of P. falciparum malaria. Closely related chemical probe molecules that retain antimalarial activity were incorporated into a broad systems biology strategy that integrates various multi-omics platforms, leading to an unbiased ...
2 days ago · In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite. For decades, the parasite’s resistance to all antimalarial drugs has posed a big challenge for researchers working to stop the spread of the disease.
