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15 hours ago · Small-molecule-induced protein degradation has emerged as a promising pharmacological modality for inactivating disease-relevant protein kinases. DYRK1A and DYRK1B are closely related protein kinases that are involved in pathological processes such as neurodegeneration, cancer development, and adaptive immune homeostasis. Herein, we report the development of the first DYRK1 proteolysis targeting chimeras (PROTACs) that combine a new ATP-competitive DYRK1 inhibitor with ligands for the E3 ...
5 days ago · From John Locke to Mr. Eko -- LOST took its time and crafted satisfying stories for the majority of its main characters. However, one character's story seemed to abruptly end without a satisfying resolution. That character was Walt Lloyd, a young boy with a special connection to the Island's source.
15 hours ago · (CNN) — Here’s a look at the life of Emmy-winning actor and writer, Chevy Chase. His grandmother nicknamed him Chevy. During college, played drums in a jazz-rock band called the Leather Canary with Donald Fagan and Walter Becker, who later formed Steely Dan. Began his writing career penning ...
5 days ago · Walt Becker 20 votes This hilarious road trip comedy stars Tim Allen, John Travolta, Martin Lawrence, and William H. Macy as a group of middle-aged friends who embark on a cross-country motorcycle journey in search of adventure.
3 days ago · Black Panther: Wakanda Forever is a 2022 American superhero film based on Marvel Comics featuring the character Shuri / Black Panther. Produced by Marvel Studios and distributed by Walt Disney Studios Motion Pictures, it is the sequel to Black Panther (2018) and the 30th film in the Marvel Cinematic Universe (MCU).
5 days ago · This list has all the most awesome movies for 7 year olds, ranked from best to worst by user votes. The best movies for 7 year olds are from many different genres and decades. Some great movies for seven year olds to watch are animated or CGI heavy, while other good films for seven year olds are live action and rich with diverse characters.
4 days ago · By Amy Becker Thursday, September 26, 2024 7:20PM "Fanatical: The Catfishing of Tegan and Sara" investigates the dark side of fame and fandom in a case of stolen identity.
