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2 days ago · Herein, we report the optimization of a series of epidermal growth factor receptor (EGFR) Exon20 insertion (Ex20Ins) inhibitors using structure-based drug design (SBDD), leading to the discovery of compound 28, a potent and wild type selective molecule, which demonstrates efficacy in multiple EGFR Ex20Ins xenograft models and blood–brain barrier penetration in preclinical species. Building on our earlier discovery of an in vivo probe, SBDD was used to design a novel bicyclic core with a ...
1 day ago · Randy S. Marsh is the most prominent parent on the show. He is a middle-class married father who alongside his wife Sharon raises their 10-year-old son Stan and 13-year-old daughter Shelley.
5 days ago · In her current storyline, Sharon has stopped seeing visions of Cassie and has recently been bombarded with hallucinations of Cameron (Linden Ashby), a dangerous old flame whom she's killed twice...
4 days ago · Sharon Tobin Kestenbaum isn’t doing this job for herself. The first woman to officially lead the board of the Weitzman National Museum of American Jewish History said that her work is designed to improve the standing of her community, but that some influence may hopefully strike close to home, too. “I didn’t realize that I was the first ...
4 days ago · Kristen Jaymes Stewart (born April 9, 1990) is an American actress. She has received various accolades, including a British Academy Film Award and a César Award, in addition to nominations for an Academy Award and a Golden Globe Award.
5 days ago · UK NED earnings start from a few thousand pounds a year, but according to executive-search firm Spencer Stuart, they can go up to £150,914. The average NED salary in 2023 was £72,0511 and the average non-executive chair fee was £434,000. 1
1 day ago · Richard L. Anderson; M. S. Bartlett; William Forest Callander; Jerome Cornfield; Besse Day; Daniel Bertrand DeLury; Paul Summer Dwyer; D. J. Finney; Harold Freeman
