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3 days ago · Tintori's grandfather, John Tintori, was 22 when he arrived in New York from Italy just 18 days earlier. In that short time, he traveled to Illinois and was hired to...
5 days ago · Hematopoietic cell kinase (Hck) is a member of the Src kinase family and is a promising drug target in myeloid leukemias. Here, we report the crystal structure of human Hck in complex with the pyrrolopyrimidine inhibitor A-419259, determined at a resolution of 1.8 Å. This structure reveals the complete Hck active site in the presence of A-419259, including the αC-helix, the DFG motif, and the activation loop. A-419259 binds at the ATP-site of Hck and induces an overall closed conformation ...
3 days ago · Vote for your favorite John Cusack movies, regardless of critic reviews or how big the role was. With more than 1,800 movie fans casting their votes, this list of the best John Cusack movies of all time is a testament to the actor's remarkable career.
2 days ago · In 1967, an anonymous baby boy was turned into a girl by doctors at Johns Hopkins Hospital. For 25 years, the case of John/Joan was called a medical triumph — proof that a child's gender identity could be changed — and thousands of "sex reassignments" were performed based on this example. But the case was a failure, the truth never reported.
2 days ago · John Wick is an American neo-noir action film series and media franchise created by Derek Kolstad. It centers on the titular character portrayed by actor Keanu Reeves. Wick is a legendary hitman who is reluctantly drawn back into the criminal underworld after retiring.
4 days ago · Two people have died in a landslide after Hurricane John slammed into Mexico’s southern coast Monday night, bringing heavy rainfall and triggering warnings of life-threatening floods.
5 days ago · John Coltrane (born September 23, 1926, Hamlet, North Carolina, U.S.—died July 17, 1967, Huntington, New York) was an American jazz saxophonist, bandleader, and composer, an iconic figure of 20th-century jazz. Coltrane’s first musical influence was his father, a tailor and part-time musician.
