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4 days ago · Data packages: a new data delivery system. Accessing data using the existing NCBI interfaces requires understanding the structure of NCBI’s databases 5.This involves understanding the kind of ...
4 days ago · An open reading frame, as related to genomics, is a portion of a DNA sequence that does not include a stop codon (which functions as a stop signal). A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genomic information encoding a particular amino acid or signaling the termination of protein synthesis ...
1 day ago · ORF expression plasmid for APOBEC3A (NM_001270406.1, isoform b) (EX-I1284-M14) C-terminal 3X-FLAG tag was acquired from GeneCopoeia. Since this isoform contained an alternative in-frame splice site resulting in a shorter sequence, site-directed mutagenesis was performed to insert the missing exon sequence and obtain APOBEC3A (NM_145699.4, isoform a).
3 days ago · OMIM is a comprehensive, authoritative compendium of human genes and genetic phenotypes that is freely available and updated daily. OMIM is authored and edited at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, under the direction of Dr. Ada Hamosh. Its official home is omim.org.
5 days ago · four ORFs were predicted in ORF Finder (https://www.ncbi.nlm. nih.gov/orf fi nder/ ): ORF4 could not translate proteins on the lncRNA antisense chain, and the other three ORFs were veri fi ed
2 days ago · The line at the upper indicated the nucleotide (nt) length and the dashed line stated the location of 5' UTR, 3' UTR, and the starting and final nucleotide for ORF. The total nucleotide length (upper rectangles), different conserved domain hits with nucleotide location, accession number (Cdd), and E-value (below rectangles) are shown in each ORF.
1 day ago · Insect mitochondrial genomes (mitogenomes) are usually represented by a conserved gene order. Whiteflies exhibit gene rearrangement in their mitogenomes; however, understanding how nucleotide substitution rates shape gene rearrangement in whiteflies is unclear due to the limited number of mitogenomes. Additionally, the mechanisms by which selection pressure drives adaptations in mitochondrial genes in the two subfamilies of whiteflies are not yet known. Here, we analyzed 18 whitefly ...
